{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T12:18:05Z","timestamp":1772281085161,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T00:00:00Z","timestamp":1447632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This retrospective chart review aimed to identify factors in childhood bacterial meningitis that predicted disease severity and long\u2010term outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 112 episodes of microbiologically confirmed bacterial meningitis in children aged three days to 15 years who were admitted to a Singapore hospital from 1998 to 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mortality rate was 6%, and 44% required intensive care unit (<jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>) admission. Predictive factors associated with <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> admission included pneumococcal meningitis, with an odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) of 5.2 and 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) of 1.5\u201318.2, leukopenia (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.6, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.7\u201317.9) and a cerebrospinal fluid (<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>):serum glucose ratio &lt;0.25 (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.5, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.4\u201314.4). An initial <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> white blood cell count &gt;1000\/mm<jats:sup>3<\/jats:sup> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.26, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.086\u20130.76) was negatively associated with <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> admission. Five years after meningitis, 32% had residual sequelae, and the associated prognostic factors were <jats:italic>Haemophilus influenzae<\/jats:italic> type b (Hib) meningitis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 29.5, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2\u2013429), seizures during their inpatient stay (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 10.6, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.9\u201360.2) and septic shock (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 8.4, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.1\u201362.1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As mortality was low in this bacterial meningitis study, <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> admission was used as a marker of disease severity. 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