{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:26:03Z","timestamp":1791653163571,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T00:00:00Z","timestamp":1450051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"I Colori della Vita Foundation, Italy"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2016,5]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Despite advances in perinatal management, there is a flat trend in incidences of respiratory distress syndrome (RDS<\/jats:styled-content>) and bronchopulmonary dysplasia (BPD<\/jats:styled-content>) in preterm infants. The main feature of BPD<\/jats:styled-content> development in preterm infants is an imbalance between increased exposure to free radicals and inadequate antioxidant defences. We investigated the associations between BPD<\/jats:styled-content> and lipid hydro\u2010peroxide (LOOH<\/jats:styled-content>) and glutathione (GSH<\/jats:styled-content>) concentrations in bronchoalveolar lavage fluid (BALF<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>In this prospective study, BALF<\/jats:styled-content> samples were collected from 44 preterm infants with RDS<\/jats:styled-content> and oxidative stress markers were measured in 11 with BPD<\/jats:styled-content> and 33 controls without BPD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>LOOH<\/jats:styled-content> levels were significantly higher (p < 0.01) in the BPD<\/jats:styled-content> group (median 16.35; 25th\u201375th centile 13.75\u201317.05 nmol\/mL) than in the no BPD<\/jats:styled-content> group (median 13.18; 25th\u201375th centile 12.92\u201313.63 nmol\/mL). Conversely, GSH<\/jats:styled-content> levels were significantly lower in the BPD<\/jats:styled-content> group (p < 0.01) (median 11.52; 25th\u201375th centile 6.95\u201313.85 \u03bc<\/jats:italic>mol\/mg) than the no BPD<\/jats:styled-content> group (median: 18.69; 25th\u201375th centile: 13.89\u201323.64 \u03bc<\/jats:italic>mol\/mg). Multiple regression analysis showed significant correlations between BPD<\/jats:styled-content> and mechanical ventilation time (p < 0.01) and LOOH<\/jats:styled-content> levels (p < 0.05).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Early LOOH<\/jats:styled-content> level increases in preterm infants developing BPD<\/jats:styled-content> suggest that lung biochemical monitoring of sick infants might be possible and BPD<\/jats:styled-content> could be predicted early by evaluating biomarkers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13233","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T09:58:51Z","timestamp":1444125531000},"page":"535-541","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The development of lung biochemical monitoring can play a key role in the early prediction of bronchopulmonary dysplasia"],"prefix":"10.1111","volume":"105","author":[{"given":"Adele","family":"Fabiano","sequence":"first","affiliation":[{"name":"Department of Maternal, Fetal and Neonatal Medicine NICU Casilino Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio W.D.","family":"Gavilanes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology School for Oncology and Developmental Biology Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc J.I.","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology School for Oncology and Developmental Biology Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris W.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology School for Oncology and Developmental Biology Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piermichele","family":"Paolillo","sequence":"additional","affiliation":[{"name":"Department of Maternal, Fetal and Neonatal Medicine NICU Casilino Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Livolti","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonetta","family":"Picone","sequence":"additional","affiliation":[{"name":"Department of Maternal, Fetal and Neonatal Medicine NICU Casilino Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Bressan","sequence":"additional","affiliation":[{"name":"Department of Maternal, Fetal and Neonatal Medicine NICU Casilino Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Gazzolo","sequence":"additional","affiliation":[{"name":"Department of Maternal, Fetal and Neonatal Medicine C. 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