{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:17:17Z","timestamp":1782793037542,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T00:00:00Z","timestamp":1447718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This was a follow\u2010up of 28 schoolchildren with cows' milk allergy (<jats:styled-content style=\"fixed-case\">CMA<\/jats:styled-content>) who attended a randomised double\u2010blind placebo\u2010controlled oral immunotherapy (<jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content>) study. In the original study, 26 (92.9%) completed the six\u2010month escalation phase, and 25 (89.3%) used milk daily at 12 months and 24 (85.7%) at 36 months. This study evaluated the outcome seven years later, with special attention paid to milk consumption and symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Outcome data were collected through a postal questionnaire completed three, four and five years after enrolment and by a phone questionnaire after seven years. We asked about the daily dose of milk products, any adverse reactions, any medication needed and possible discontinuation of daily milk consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were available at the seven\u2010year point for 24 children and 14 (58.3%) of these continued to use milk (\u2265200 mL) or milk products (protein \u22656400 mg) daily for seven years. However, three (21.4%) of these still reported symptoms associated with milk consumption. Of the 10 remaining children, two children used milk products daily but consumed less due to symptoms and eight (33.3%) had discontinued milk consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oral immunotherapy was an effective and safe way of desensitising schoolchildren with persistent <jats:styled-content style=\"fixed-case\">CMA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13251","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T08:04:21Z","timestamp":1445933061000},"page":"215-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Children who were treated with oral immunotherapy for cows' milk allergy showed long\u2010term desensitisation seven years later"],"prefix":"10.1111","volume":"105","author":[{"given":"Marita","family":"Paassilta","sequence":"first","affiliation":[{"name":"Allergy Centre Tampere University Hospital Tampere Finland"},{"name":"Centre for Child Health Research Tampere University and University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Salmivesi","sequence":"additional","affiliation":[{"name":"Allergy Centre Tampere University Hospital Tampere Finland"},{"name":"Centre for Child Health Research Tampere University and University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiina","family":"M\u00e4ki","sequence":"additional","affiliation":[{"name":"Allergy Centre Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Helminen","sequence":"additional","affiliation":[{"name":"Science Centre Pirkanmaa Hospital District and School of Health Sciences University of Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Korppi","sequence":"additional","affiliation":[{"name":"Centre for Child Health Research Tampere University and University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.11.020"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2014.09.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.09.016"},{"key":"e_1_2_8_6_1","first-page":"12","article-title":"Oral desensitization in children with milk and egg allergies obtains recovery in a significant proportion of cases. 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