{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:25:22Z","timestamp":1780097122619,"version":"3.54.0"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T00:00:00Z","timestamp":1453161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Albumin and pre\u2010albumin are frequently used as nutritional markers in clinical practice. We examined whether serum albumin and pre\u2010albumin were predicted by body mass index (BMI), hydration and\/or inflammation in female adolescents with a recently diagnosed restrictive eating disorder (RED).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of female adolescents with RED from 2002 to 2011. Low albumin and pre\u2010albumin levels were defined as &lt;3.5 g\/dL and &lt;20 mg\/dL, respectively. We assessed inflammation using the erythrocyte sedimentation rate (ESR) and dehydration using the haematocrit levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 75 females with a mean age of 15.2 years and 64% had a BMI Z score of &lt;\u22122. The mean albumin and pre\u2010albumin levels were 4.8 g\/dL and 22.2 mg\/dL, respectively, with 24% of the children having low pre\u2010albumin and none having low albumin levels. The stepwise multiple regression for albumin identified ESR and haematocrit as significant predictors, which explained 14.8% of the variance. Age was the only significant predictor for pre\u2010albumin, which explained 15.3% of the variance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Albumin, but not pre\u2010albumin, levels were primarily predicted by low\u2010grade inflammation and hydration, but not by BMI. These markers should not be used to assess nutritional status in adolescents with RED.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13312","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T12:07:04Z","timestamp":1450181224000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Albumin and pre\u2010albumin levels do not reflect the nutritional status of female adolescents with restrictive eating disorders"],"prefix":"10.1111","volume":"105","author":[{"given":"Koen","family":"Huysentruyt","sequence":"first","affiliation":[{"name":"Department of Paediatrics Universitair Ziekenhuis Brussel Vrije Universiteit Brussel (VUB), Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"De Schepper","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Universitair Ziekenhuis Brussel Vrije Universiteit Brussel (VUB), Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Vanbesien","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Universitair Ziekenhuis Brussel Vrije Universiteit Brussel (VUB), Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvan","family":"Vandenplas","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Universitair Ziekenhuis Brussel Vrije Universiteit Brussel (VUB), Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13014"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.03.032"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.09.031"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2004.08.022"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19890050"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/03014460903049074"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1972.32.5.712"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.03.032"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22233"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.01.006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2012.03.020"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400607"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.13312","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.13312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T12:43:30Z","timestamp":1695732210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.13312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,19]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/apa.13312"],"URL":"https:\/\/doi.org\/10.1111\/apa.13312","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,19]]},"assertion":[{"value":"2015-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}