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We analysed the evolution of natraemia and explored any adverse effects on children treated with intravenous isotonic fluids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective study of 50 patients consecutively admitted to a general paediatric ward who were treated with isotonic intravenous fluids and on a nil by mouth diet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most prevalent diagnosis was acute gastroenteritis (64%). Hyponatraemia, defined as sodium in plasma of &lt;135 <jats:styled-content style=\"fixed-case\">mE<\/jats:styled-content>q\/L, affected 22% of the subjects, but none displayed this during the first postadmission analysis at a median of eight hours. Sodium levels changed by an average of +0.64 <jats:styled-content style=\"fixed-case\">mE<\/jats:styled-content>q\/L\/hour. The subgroup analysis (0.91 versus 0.56 <jats:styled-content style=\"fixed-case\">mE<\/jats:styled-content>q\/L\/hour, p = 0.02) and multiple linear regression (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.756) showed a greater increase in sodium when patients had hyponatraemia on admission. Iatrogenic hyponatraemia was not detected, but two patients showed mild hypernatraemia and 35% developed clinically insignificant hyperchloraemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using intravenous isotonic fluids induced a positive trend in natraemia on a general paediatric ward, particularly if patients were hyponatraemic when admitted, and did not induce clinically relevant adverse effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13316","type":"journal-article","created":{"date-parts":[[2015,12,19]],"date-time":"2015-12-19T06:24:05Z","timestamp":1450506245000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intravenous isotonic fluids induced a positive trend in natraemia in children admitted to a general paediatric ward"],"prefix":"10.1111","volume":"105","author":[{"given":"Juan Diego","family":"Toledo","sequence":"first","affiliation":[{"name":"Department of Pediatrics General and University Hospital Castellon Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Morell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics General and University Hospital Castellon Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximo","family":"Vento","sequence":"additional","affiliation":[{"name":"Division of Neonatology University and Polytechnic Hospital La Fe Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6836.1218"},{"key":"e_1_2_8_3_1","first-page":"21","article-title":"Hospital\u2010acquired acute hyponatremia and reports of pediatric deaths","volume":"21","author":"Koczmara C","year":"2010","journal-title":"Dynamics"},{"key":"e_1_2_8_4_1","unstructured":"National Patient Safety Agency(2007).Reducing the risk of hyponatraemia when administering intravenous infusions to children. 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