{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:08:49Z","timestamp":1790813329907,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T00:00:00Z","timestamp":1456704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Lucile Packard Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2016,5]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Relative contributions of increased production [by end\u2010tidal carbon monoxide concentrations (ETCO<\/jats:styled-content>c)] and decreased elimination of bilirubin to predischarge hour\u2010specific total bilirubin (TB<\/jats:styled-content>) levels were assessed in healthy late\u2010preterm and term newborns. Secondly, we report predischarge ETCO<\/jats:styled-content>c ranges to guide clinical management of hyperbilirubinemia.<\/jats:p><\/jats:sec>Methods<\/jats:title>TB<\/jats:styled-content> and ETCO<\/jats:styled-content>c (\u22643 timepoints) determinations of newborns aged between six hours and <6 days (n = 79) were stratified by postnatal age epochs. Hyperbilirubinemia risk was assessed by plotting TB<\/jats:styled-content> values as a function of ETCO<\/jats:styled-content>c.<\/jats:p><\/jats:sec>Results<\/jats:title>Stratifications of ETCO<\/jats:styled-content>c (in ppm, mean, median and interquartile ranges) by postnatal age epochs (0\u201324, 24\u201348 and 48\u201372) were as follows: 2.0, 1.9, 1.8\u20132.2 (n = 11); 1.6, 1.5, 1.1\u20132.0 (n = 58); and 2.0, 1.8, 1.6\u20132.3 (n = 9), respectively. Infants with ETCO<\/jats:styled-content>c \u2265 2.5 were at high risk, between 1.5 and 2.5 at moderate risk and \u22641.5 were at low risk. Risk due to haemolysis alone was not independent (p < 0.01). For infants with TB<\/jats:styled-content> >75th percentile (n = 31), 23% had ETCO<\/jats:styled-content> \u22641.5, and 77% had ETCO<\/jats:styled-content>c > 1.5 (p < 0.00003).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Near\u2010simultaneous ETCO<\/jats:styled-content>c and TB<\/jats:styled-content> measurements in infants with TB<\/jats:styled-content> >75th percentile accurately identify haemolytic hyperbilirubinemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13341","type":"journal-article","created":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T15:12:45Z","timestamp":1453561965000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Identification of neonatal haemolysis: an approach to predischarge management of neonatal hyperbilirubinemia"],"prefix":"10.1111","volume":"105","author":[{"given":"Vinod K.","family":"Bhutani","sequence":"first","affiliation":[{"name":"Division of Neonatal and Developmental Medicine Department of Pediatrics Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanmukha","family":"Srinivas","sequence":"additional","affiliation":[{"name":"Division of Neonatal and Developmental Medicine Department of Pediatrics Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin E.","family":"Castillo Cuadrado","sequence":"additional","affiliation":[{"name":"Division of Neonatal and Developmental Medicine Department of Pediatrics Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janelle L.","family":"Aby","sequence":"additional","affiliation":[{"name":"Division of General Pediatrics Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald 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