{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:57:36Z","timestamp":1789498656404,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T00:00:00Z","timestamp":1457222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The association between <jats:italic>Helicobacter pylori<\/jats:italic> infection and gastrointestinal symptoms is debatable in childhood. We examined the potential relationship between <jats:italic>H. pylori<\/jats:italic> infection and gastrointestinal symptoms in Brazilian children with nonulcer dyspepsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective observational study analysed 240 Brazilian children and adolescents (68.7% girls) with chronic nonulcer dyspepsia, who underwent upper gastrointestinal endoscopy and biopsy. Their mean age was 9.8 years (range 4\u201317). Upper gastrointestinal symptoms, including abdominal pain, nausea, burning, early satiety, belching and weigh loss, were evaluated by a questionnaire and <jats:italic>H. pylori<\/jats:italic> infection was determined by histopathology of gastric biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>H. pylori<\/jats:italic> infection was identified in 123\/240 patients (52%). There was no significant association between the <jats:italic>H. pylori<\/jats:italic> infection and gastrointestinal symptoms and no relationship between the infection and abdominal pain or pain characteristics. However, nausea was significantly associated with the <jats:italic>H. pylori<\/jats:italic> infection, with an odds ratio of 1.76 and 95% confidence interval of 1.1\u20132.94 p &lt; 0.03. Symptoms lasting longer than 12 months were significantly more frequent in children with pangastritis than in those with antral gastritis (p &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of <jats:italic>H. pylori<\/jats:italic> infection was high in Brazilian children with nonulcer dyspepsia, but was not associated with specific signs and symptoms, except for nausea.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13347","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T14:36:43Z","timestamp":1453991803000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["<i>Helicobacter pylori<\/i> infection is high in paediatric nonulcer dyspepsia but not associated with specific gastrointestinal symptoms"],"prefix":"10.1111","volume":"105","author":[{"given":"RGS","family":"Correa Silva","sequence":"first","affiliation":[{"name":"Gastroenterology Unit Department of Pediatrics Botucatu Medical School Unesp Univ Estadual Paulista Botucatu SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NC","family":"Machado","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Department of Pediatrics Botucatu Medical School Unesp Univ Estadual Paulista Botucatu SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Department of Pediatrics Botucatu Medical School Unesp Univ Estadual Paulista Botucatu SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAM","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Pathology Botucatu Medical School Unesp Univ Estadual Paulista Botucatu SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302084"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-012-1823-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12070"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.10.069"},{"key":"e_1_2_10_6_1","first-page":"CD002096","article-title":"Eradication of Helicobacter pylori for non\u2010ulcer dyspepsia","volume":"1","author":"Moayyedi P","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2002.00109.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2006.00412.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00776.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0941"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.08.063"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MPG.0000154661.39488.AC"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200107000-00004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182618136"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0131"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000215307.48169.7b"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00766.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-31802010000400002"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2012.00955.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1179\/1465328110Y.0000000004"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182227e90"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/1999\/591767"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.13347","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.13347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T20:58:41Z","timestamp":1695761921000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.13347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,6]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/apa.13347"],"URL":"https:\/\/doi.org\/10.1111\/apa.13347","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,6]]},"assertion":[{"value":"2015-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}