{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:12:36Z","timestamp":1762506756471},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Technology Development Fund of Iceland"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>A well\u2010documented, clinically proven <jats:italic>per<\/jats:italic> rectum treatment for childhood constipation is needed. This phase two clinical trial evaluated the efficacy of suppositories containing free fatty acids (<jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>) compared with Klyx docusate sodium and sorbitol enemas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomised, controlled, single\u2010blind study was undertaken on 77 children aged between one and 17 who presented to an emergency department in Iceland and were diagnosed with constipation. In stage one, 23 patients were randomised to receive lower dose <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content> suppositories or Klyx (n = 33). In stage two, 21 different patients were randomised to receive higher dose suppositories and compared with the same Klyx control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The suppositories were effective at bowel emptying in 39% of the group who received the lower <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content> doses and 81% of the group receiving higher doses, compared with 88% in the Klyx control group. Symptom relief was obtained in 30% of the group receiving the lower doses and 71% of the group receiving the higher doses, compared with 73% in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The higher dose <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content> suppositories were as effective as the Klyx enemas with regard to bowel emptying and symptom relief and might provide an important and less invasive alternative for childhood constipation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13394","type":"journal-article","created":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T12:57:40Z","timestamp":1457355460000},"page":"689-694","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Free fatty acid suppositories are as effective as docusate sodium and sorbitol enemas in treating constipation in 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