{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:51:04Z","timestamp":1787237464190,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      We previously reported a protective effect of maternal omega\u20103 fatty acid supplements on the development of immunoglobulin E (IgE)\u2010associated disease in infancy. This study assessed omega\u20103 long\u2010chain polyunsaturated fatty acids (\n                      <jats:styled-content style=\"fixed-case\">LCPUFA<\/jats:styled-content>\n                      ) in maternal milk in relation to omega\u20103\n                      <jats:styled-content style=\"fixed-case\">LCPUFA<\/jats:styled-content>\n                      supplementation and the development of allergic disease in their infants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study randomised 95 pregnant women at risk of having an allergic infant, to daily supplements of 2.6 g omega\u20103\n                      <jats:styled-content style=\"fixed-case\">LCPUFA<\/jats:styled-content>\n                      or a placebo of 2.7 g soya bean oil from gestational week 25 until 3 months of lactation. Breast milk samples were collected as colostrum, at one and 3 months. Milk fatty acids were related to allergic outcome in the infants at 24 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Omega\u20103 milk fatty acids were higher in women who received omega\u20103 supplements than the placebo group (p &lt; 0.01). Higher proportions of milk eicosapentaenoic acid and docosahexaenoic acid and a lower arachidonic\/eicosapentaenoic acid ratio were associated with an absence of IgE\u2010associated disease in the infants. None of the children developed IgE\u2010associated atopic eczema above a level of 0.83 mol% eicosapentaenoic acid in colostrum. [Correction added on 7 July 2016, after online publication: In the preceding sentence, the correct word should be \u201cabove\u201d instead of \u201cbelow\u201d and this has been amended in this current version.]<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      High omega\u20103\n                      <jats:styled-content style=\"fixed-case\">LCPUFA<\/jats:styled-content>\n                      milk levels in mothers who received omega\u20103\n                      <jats:styled-content style=\"fixed-case\">LCPUFA<\/jats:styled-content>\n                      supplements were related to fewer allergies in their children.\n                    <\/jats:p>\n                  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