{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:50:36Z","timestamp":1767851436064,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T00:00:00Z","timestamp":1466726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study determined current international clinical practice and opinions regarding initial fractional inspired oxygen (FiO<jats:sub>2<\/jats:sub>) and pulse oximetry (SpO<jats:sub>2<\/jats:sub>) targets for delivery room resuscitation of preterm infants of less than 29 weeks of gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An online survey was disseminated to neonatal clinicians via established professional clinical networks using a web\u2010based survey programme between March 9 and June 30, 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 630 responses from 25 countries, 60% were from neonatologists. The majority (77%) would target SpO<jats:sub>2<\/jats:sub> between the 10th to 50th percentiles values for full\u2010term infants. The median starting FiO<jats:sub>2<\/jats:sub> was 0.3, with Japan using the highest (0.4) and the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> using the lowest (0.21). New Zealand targeted the highest SpO<jats:sub>2<\/jats:sub> percentiles (median 50%). Most respondents agreed or did not disagree that a trial was required that compared the higher FiO<jats:sub>2<\/jats:sub> of 0.6 (83%), targeting the 50th SpO<jats:sub>2<\/jats:sub> percentile (60%), and the lower FiO<jats:sub>2<\/jats:sub> of 0.21 (80%), targeting the 10th SpO<jats:sub>2<\/jats:sub> percentile (78%). Most (65%) would join this trial. Many considered that evidence was lacking and further research was needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinicians currently favour lower SpO<jats:sub>2<\/jats:sub> targets for preterm resuscitation, despite acknowledging the lack of evidence for benefit or harm, and 65% would join a clinical trial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13485","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T14:27:29Z","timestamp":1464272849000},"page":"1061-1066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Clinicians in 25 countries prefer to use lower levels of oxygen to resuscitate preterm infants at birth"],"prefix":"10.1111","volume":"105","author":[{"given":"Ju Lee","family":"Oei","sequence":"first","affiliation":[{"name":"School of Women's and Children's Health The University of New South Wales Kensington NSW Australia"},{"name":"Department of Newborn Care The Royal Hospital for Women Randwick NSW Australia"},{"name":"NHMRC Clinical Trials Centre University of Sydney Camperdown NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alpana","family":"Ghadge","sequence":"additional","affiliation":[{"name":"NHMRC Clinical Trials Centre University of Sydney Camperdown NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Coates","sequence":"additional","affiliation":[{"name":"NHMRC Clinical Trials Centre University of Sydney Camperdown NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian M.","family":"Wright","sequence":"additional","affiliation":[{"name":"Illawarra Health and Medical Research Institute and Graduate School of Medicine The University of Wollongong Wollongong NSW Australia"},{"name":"Department of Neonatology The John Hunter Hospital Newcastle NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola D.","family":"Saugstad","sequence":"additional","affiliation":[{"name":"Department of Pediatric Research Oslo University Hospital The University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximo","family":"Vento","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Valencia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Buonocore","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Nagashima","sequence":"additional","affiliation":[{"name":"National Home Doctor Service Spring Hill QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University School of Medicine Isehara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiguhero","family":"Hosono","sequence":"additional","affiliation":[{"name":"School of Medicine Nihon University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.","family":"Davis","sequence":"additional","affiliation":[{"name":"The Royal Women's Hospital Melbourne VIC Australia"},{"name":"Department of Paediatrics University of Melbourne Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Craven","sequence":"additional","affiliation":[{"name":"Department of Neonatology The John Hunter Hospital Newcastle NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Askie","sequence":"additional","affiliation":[{"name":"NHMRC Clinical Trials Centre University of Sydney Camperdown NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Dawson","sequence":"additional","affiliation":[{"name":"The Royal Women's Hospital Melbourne VIC Australia"},{"name":"Department of Paediatrics University of Melbourne Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalabh","family":"Garg","sequence":"additional","affiliation":[{"name":"South Tees Hospitals Middlesborough UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Keech","sequence":"additional","affiliation":[{"name":"NHMRC Clinical Trials Centre University of Sydney Camperdown NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yacov","family":"Rabi","sequence":"additional","affiliation":[{"name":"Alberta Children's Hospital Research Institute University of Calgary Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Smyth","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health The University of New South Wales Kensington NSW Australia"},{"name":"Department of Newborn Care The Royal Hospital for Women Randwick NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Sinha","sequence":"additional","affiliation":[{"name":"South Tees Hospitals Middlesborough UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Stenson","sequence":"additional","affiliation":[{"name":"Simpson Centre for Reproductive Health Royal Infirmary of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Lui","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health The University of New South Wales Kensington NSW Australia"},{"name":"Department of Newborn Care The Royal Hospital for Women Randwick NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol Lu","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Newborn Care The Royal Hospital for Women Randwick NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Tarnow Mordi","sequence":"additional","affiliation":[{"name":"NHMRC Clinical Trials Centre University of Sydney Camperdown NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The HOLISTIC (Higher Or Lower oxygen and Infant Saturation Targeting: International Collaboration) Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199312000-00023"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.1.e1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0350"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.971127"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17189-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000244356"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12656"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2008.01430.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2012.02545.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2014.04.024"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3373D"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.12.015"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1510"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200412-1740OC"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0434"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.73.2.F81"},{"key":"e_1_2_9_18_1","first-page":"17","article-title":"Targeted oxygen in the resuscitation of preterm infants and their developmental outcomes \u2013 the TO2RPIDO study","volume":"51","author":"Oei J","year":"2015","journal-title":"J Paed Child Health"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1460"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1984"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3130"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0978"},{"key":"e_1_2_9_23_1","unstructured":"Vento\u2010TorresM AguarM IzquierdoM BrugadaM IriondoM EscobarJ et al.Higher (60%) VS. lower (30%) initial oxygen inspiratory fraction for ventilation of preterm infants in the delivery room: a randomized double blinded pilot study. Abstracts of the 54th Annual Meeting of the European Society for Paediatric Research 2013. Available at:http:\/\/www.espr.info\/templates\/espr\/images\/pdf\/9349_abstract_book_-_25sett13-it-it.pdf(accessed on December 20 2015)."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.02.019"},{"key":"e_1_2_9_25_1","unstructured":"KumarVH WynnK RyanRM NielsenL ReynoldsAM CarrionV.Randomized trial of varying levels of oxygen (21% 40% and 100%) at resuscitation in premature infants < 32 weeks GA.Abstracts of the Pediatric Academic Societies Meeting.2012;4525.352."},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.08-221"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.059287"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2015.07.045"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.13485","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.13485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T21:44:40Z","timestamp":1695764680000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.13485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,24]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/apa.13485"],"URL":"https:\/\/doi.org\/10.1111\/apa.13485","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,24]]},"assertion":[{"value":"2015-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}