{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:16:53Z","timestamp":1768288613166,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T00:00:00Z","timestamp":1466985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>No information was available on how fast intravenous cefuroxime administered to pregnant women before a Caesarean section was cleared in newborn infants. This study investigated the drug's half\u2010life and the exposure of healthy newborn infants after their mothers received the drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Healthy mothers received a single dose of cefuroxime 15\u201360 minutes before skin incision. One blood sample was drawn from the umbilical cord, and two blood samples were drawn from the infant after delivery. Total plasma cefuroxime (\u03bcg\/mL) was measured using high\u2010pressure liquid chromatography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cefuroxime was given to 22 mothers, including two who had twins. The concentration of cefuroxime varied significantly among infants (p &lt; 0.001), while the rate of decline did not (p = 0.24). The median cefuroxime half\u2010life was 3.5 hours (range 2.9\u20135.5), which was approximately three times longer than in normal adults and seemed to clear within 24 hours. The median area under the concentration\u2013time curve was 65.0 hour \u03bcg\/mL (range 31.7\u2013162.4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found that the cefuroxime half\u2010life after a Caesarean section varied among infants and was longer than in normal adults but cleared within 24 hours. Exposure to cefuroxime in newborn infants may influence the gut microbiota and should be investigated further.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13489","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T11:16:44Z","timestamp":1464693404000},"page":"1074-1078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The half\u2010life and exposure of cefuroxime varied in newborn infants after a Caesarean section"],"prefix":"10.1111","volume":"105","author":[{"given":"G","family":"Zachariassen","sequence":"first","affiliation":[{"name":"Hans Christian Andersen Children's Hospital Odense University Hospital and University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Hyldig","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Odense University Hospital and University of Southern Denmark  Odense Denmark"},{"name":"OPEN Odense Patient data Explorative Network Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JS","family":"Joergensen","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Odense University Hospital and University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DS","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Food Science University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Greisen","sequence":"additional","affiliation":[{"name":"Neonatal Unit Rigshospitalet and University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,27]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"Cd007482","article-title":"Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section","volume":"1","author":"Smaill FM","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_3_1","first-page":"585","article-title":"Antibiotic prophylaxis to prevent surgical site infections","volume":"83","author":"Salkind AR","year":"2011","journal-title":"Am Fam Physician"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181ad5fca"},{"key":"e_1_2_11_5_1","unstructured":"SandbjergGuideline2012. Available at:http:\/\/gynobsguideline.dk\/sandbjerg\/120425%20ANTIBIOTIKA%20endelig%2025%204%2012.pdf(accessed on April 9 2016)."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.077"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318197c3b6"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12036"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-002028"},{"key":"e_1_2_11_10_1","first-page":"Cd009516","article-title":"Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing cesarean delivery","volume":"12","author":"Mackeen AD","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.12.002"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002601107"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12186"},{"key":"e_1_2_11_14_1","unstructured":"Promedicin.dk. Available at:http:\/\/pro.medicin.dk\/Search\/Search\/Search\/Cefuroxim(accessed on April 4 2016)."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03857-14"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.9.5.741"},{"issue":"9","key":"e_1_2_11_17_1","first-page":"179","article-title":"Pharmacokinetics and clinical efficacy of cefuroxime in the newborn period","volume":"70","author":"Renlund M","year":"1977","journal-title":"Proc R Soc Med"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(94)90278-X"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-013-0117-y"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2003.10.006"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1361825"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.13489","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.13489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T21:43:50Z","timestamp":1695764630000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.13489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,27]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/apa.13489"],"URL":"https:\/\/doi.org\/10.1111\/apa.13489","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,27]]},"assertion":[{"value":"2016-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}