{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:55:18Z","timestamp":1762376118536},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T00:00:00Z","timestamp":1471305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003409","name":"GABA International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003142","name":"Fonds NutsOhra","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003142","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Coeliac disease can induce specific enamel defects (<jats:styled-content style=\"fixed-case\">SED<\/jats:styled-content>), but little is known about the consequences of antitissue transglutaminase (<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>2A) autoimmunity. We investigated whether <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>2A positivity in children and their mothers was associated with <jats:styled-content style=\"fixed-case\">SED<\/jats:styled-content> in the primary dentition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Maternal and child serum immunoglobulin A\u2010<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>2A levels were measured as part of the Generation R prospective cohort study. Clinical oral photographs of the primary dentition were taken, and <jats:styled-content style=\"fixed-case\">SED<\/jats:styled-content> and caries were recorded. We performed logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analysed data on 4775 mothers and 4233 children (median age of 6.2 \u00b1 0.5 years). <jats:styled-content style=\"fixed-case\">SED<\/jats:styled-content> and caries were not associated with maternal <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>2A levels. The 59 <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>2A\u2010positive children tended to have more <jats:styled-content style=\"fixed-case\">SED<\/jats:styled-content>, particularly the 31 in the strongly positive subgroup, with odds ratio of 1.72 and 2.29, respectively. A positive linear trend was observed between higher <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>2A levels and paediatric <jats:styled-content style=\"fixed-case\">SED<\/jats:styled-content> (p = 0.04), but this became nonsignificant after adjusting for ethnic and socio\u2010economic background. No difference in caries was found between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>2A did not play an independent role on <jats:styled-content style=\"fixed-case\">SED<\/jats:styled-content> in the primary dentition during pregnancy and childhood, and the relationship may be explained by ethnic and socio\u2010economic background.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13533","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T06:46:39Z","timestamp":1469083599000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Generation R birth cohort study shows that specific enamel defects were not associated with elevated serum transglutaminase type 2 antibodies"],"prefix":"10.1111","volume":"105","author":[{"given":"Sytske A.","family":"Beth","sequence":"first","affiliation":[{"name":"The Generation R Study Group Erasmus University Medical Center Rotterdam The Netherlands"},{"name":"Department of Pediatrics Erasmus University Medical Center Rotterdam The Netherlands"},{"name":"Department of Immunology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle A. 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