{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:31:10Z","timestamp":1792812670721,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T00:00:00Z","timestamp":1476057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Children's Research Centre, Crumlin, Dublin, Ireland"},{"name":"Children's University Hospital, Temple Street, Dublin, Ireland"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Perinatal asphyxia is associated with multi\u2010organ injury including acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>). New urinary biomarkers may detect more subtle renal injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Urinary biomarkers (albumin, beta\u20102 microglobulin, cystatin\u2010C, epidermal growth factor, neutrophil gelatinase\u2010associated lipocalin, osteopontin, uromodulin) were serially measured from days 1 to 7 in term infants with perinatal asphyxia and controls and compared to \u2018Kidney Disease Improving Global Outcome\u2019 scoring of renal injury and to encephalopathy grade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 255 urine samples were taken from infants exposed to perinatal asphyxia (n\u00a0=\u00a082) and term controls (n\u00a0=\u00a010). Thirty\u2010nine infants underwent therapeutic hypothermia, four died and 30 infants had acute kidney injury. Infants with acute kidney injury had significantly higher levels of urinary albumin (day 2), cystatin\u2010C (days 1, 2, 3 and 7), neutrophil gelatinase\u2010associated lipocalin (days 2, 3 and 7) and osteopontin (days 2, 3 and 7) and lower epidermal growth factor and uromodulin (day 1) compared to those without <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>. Day 2 cystatin\u2010C predicted <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> with an area under receiver operating characteristic curve of 0.89, p\u00a0&lt;\u00a00.001, cut\u2010off 9.8\u00a0\u00d7\u00a010<jats:sup>4\u00a0<\/jats:sup>pg\/mL. <jats:styled-content style=\"fixed-case\">NE<\/jats:styled-content> grade <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> infants had significantly elevated levels of urinary cystatin\u2010C, neutrophil gelatinase\u2010associated lipocalin and decreased <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content> compared to grade 0\/I infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Asphyxiated infants who develop acute kidney injury have significantly altered urinary biomarkers postnatally. Validation of neonatal <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> urinary biomarkers in a large prospective study is required. Long\u2010term follow\u2010up of infants post\u2010asphyxial insult for chronic renal injury is advised.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13555","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T14:12:46Z","timestamp":1471961566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Renal function and novel urinary biomarkers in infants with neonatal encephalopathy"],"prefix":"10.1111","volume":"105","author":[{"given":"Deirdre U.","family":"Sweetman","sequence":"first","affiliation":[{"name":"Department of Neonatology National Maternity Hospital Dublin Ireland"},{"name":"National Children's Research Centre Crumlin Dublin Ireland"},{"name":"Department of Paediatrics Royal College of Surgeons in Ireland Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chike","family":"Onwuneme","sequence":"additional","affiliation":[{"name":"Department of Neonatology National Maternity Hospital Dublin Ireland"},{"name":"UCD School of Medicine and Medical Sciences University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Watson","sequence":"additional","affiliation":[{"name":"UCD School of Medicine and Medical Sciences University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"O'Neill","sequence":"additional","affiliation":[{"name":"UCD School of Medicine and Medical Sciences University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.A.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Neonatology National Maternity Hospital Dublin Ireland"},{"name":"UCD School of Medicine and Medical Sciences University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor J.","family":"Molloy","sequence":"additional","affiliation":[{"name":"National Children's Research Centre Crumlin Dublin Ireland"},{"name":"Department of Paediatrics Royal College of Surgeons in Ireland Dublin Ireland"},{"name":"UCD School of Medicine and Medical Sciences University College Dublin Dublin Ireland"},{"name":"Department of Paediatrics Trinity College Dublin National Children's Hospital Tallaght &amp; 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