{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:10:44Z","timestamp":1778065844223,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T00:00:00Z","timestamp":1476057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi Aventis","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Laboratoires Guigoz"},{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise de P\u00e9diatrie"},{"name":"Groupe de P\u00e9diatrie G\u00e9n\u00e9rale"},{"name":"Groupe de Recherches Epid\u00e9miologiques en P\u00e9diatrie"},{"name":"Sorbonne Universit\u00e9s"},{"name":"UPMC Univ Paris 06"},{"name":"Ecole Doctorale 393"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Controversy surrounding the safety of nonsteroidal anti\u2010inflammatory drugs (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s) provides an opportunity to study parents\u2019 and healthcare professionals\u2019 differential use of over\u2010the\u2010counter drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this national cross\u2010sectional study, general practitioners, paediatricians and pharmacists were asked to include up to five consecutive febrile paediatric patients aged 1\u00a0month to 12\u00a0years. Parents and healthcare professionals completed questionnaires about the current fever episode. We studied the differential use of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s by parents and healthcare professionals notably in three clinical conditions with various estimated risk of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s complications: varicella, gastroenteritis and pharyngitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 1534 healthcare professionals prescribed 15% of the 6596 children with an <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>, but 32% of the parents gave their child an <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>. Generally, <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> use was associated with older children, higher temperatures, pain due to otitis and the absence of a rash or gastroenteritis. The differential use of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s by parents and professionals was greater in conditions with high than low estimated risks of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> complications, with odds ratios ranging from to 9.0 to 2.9, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The differential use of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s by healthcare professionals and parents for clinical conditions with potential risks should prompt discussions about the safety of their over\u2010the\u2010counter status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13566","type":"journal-article","created":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T06:47:13Z","timestamp":1472712433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["National cross\u2010sectional study of nonsteroidal anti\u2010inflammatory drugs use highlights differences between parents and professionals and prompts safety concerns"],"prefix":"10.1111","volume":"105","author":[{"given":"Nathalie","family":"Bertille","sequence":"first","affiliation":[{"name":"Inserm U1153 Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epop\u00e9) Center for Epidemiology and Statistics, Sorbonne Paris Cit\u00e9 (CRESS) Paris\u00a0Descartes University Paris France"},{"name":"Sorbonne Universit\u00e9s UPMC Univ Paris 06, IFD Paris France"},{"name":"Department of General Paediatrics H\u00f4pital Necker\u2010Enfants malades Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9rard","family":"Pons","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Groupe hospitalier Cochin\u2010Broca\u2010H\u00f4tel Dieu, AP\u2010HP Paris Descartes University Paris France"},{"name":"Inserm U663 Paediatric Epilepsies and Brain Plasticity Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Fournier\u2010Charri\u00e8re","sequence":"additional","affiliation":[{"name":"Pain Center H\u00f4pital Bic\u00eatre, AP\u2010HP Le Kremlin Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babak","family":"Khoshnood","sequence":"additional","affiliation":[{"name":"Inserm U1153 Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epop\u00e9) Center for Epidemiology and Statistics, Sorbonne Paris Cit\u00e9 (CRESS) Paris\u00a0Descartes University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Chalumeau","sequence":"additional","affiliation":[{"name":"Inserm U1153 Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epop\u00e9) Center for Epidemiology and Statistics, Sorbonne Paris Cit\u00e9 (CRESS) Paris\u00a0Descartes University Paris France"},{"name":"Department of General Paediatrics H\u00f4pital Necker\u2010Enfants malades Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-003-1392-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.08.051"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520360043037"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-302100"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-010-0832-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.5.619"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.02997.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/11532890-000000000-00000"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/338460"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2011.05.024"},{"key":"e_1_2_10_12_1","unstructured":"National Institute for Health and Clinical Excellence.Feverish illness in children \u2010 Assessment and initial management in children younger than 5\u00a0years 2007. Available at:http:\/\/www.rcpch.ac.uk\/sites\/default\/files\/asset_library\/Research\/Clinical%20Effectiveness\/Endorsed%20guidelines\/Feverish%20Illness%20in%20Children%20(NICE)\/Feverish%20illness%20in%20children.full%20guideline.pdf(accessed on April 5 2013)."},{"key":"e_1_2_10_13_1","unstructured":"American Academy of Pediatrics.Healthy Children. Fever.2012 Available at:http:\/\/www.healthychildren.org\/English\/health-issues\/conditions\/fever\/Pages\/default.aspx(accessed on January 31 2013)."},{"key":"e_1_2_10_14_1","unstructured":"Community Paediatrics Committee.Fever and temperature taking 2013. Available at:http:\/\/www.caringforkids.cps.ca\/handouts\/fever_and_temperature_taking(accessed on October 4 2015)."},{"key":"e_1_2_10_15_1","unstructured":"Societe Francaise de Pediatrie \u2010 Groupe de Pediatrie Generale. [Prise en charge symptomatique de la fi\u00e8vre du jeune enfant] 2004. Available at:http:\/\/www.sfpediatrie.com\/recommandation\/prise-en-charge-symptomatique-de-la-fi%C3%A8vre-du-jeune-enfant(accessed on January 24 2013)."},{"key":"e_1_2_10_16_1","unstructured":"Agence nationale de s\u00e9curit\u00e9 du m\u00e9dicament et des produits de sant\u00e9. [Informations sur les traitements de la fi\u00e8vre chez l'enfant] 2005. Available at:http:\/\/www.ansm.sante.fr\/var\/ansm_site\/storage\/original\/application\/b439d55ee299ae83db7bd9008c1eb267.pdf(accessed on April 5 2013)."},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.118810"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1481803500007892"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pec.0000139739.46591.dd"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2007.01161.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.6.1241"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083469"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2006.12.018"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143230"},{"key":"e_1_2_10_25_1","unstructured":"Cegedim Group.Software for healthcare professionals 2012. Available at:http:\/\/www.cegedim.com\/Pages\/default.aspx(accessed on October 14 2015)."},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0755-4982(05)84136-3"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-66"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aenj.2013.10.002"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M332"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta13270"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13221"},{"key":"e_1_2_10_32_1","unstructured":"Agence nationale de s\u00e9curit\u00e9 du m\u00e9dicament et des produits de sant\u00e9. [Mise au point sur la prise charge de la fi\u00e8vre chez l'enfant] 2005. Available at:http:\/\/www.ansm.sante.fr\/content\/download\/6212\/60216\/version\/4\/file\/mapfiev.pdf(accessed on September 17 2015)."}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.13566","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.13566","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.13566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T03:13:21Z","timestamp":1696475601000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.13566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,10]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/apa.13566"],"URL":"https:\/\/doi.org\/10.1111\/apa.13566","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,10]]},"assertion":[{"value":"2015-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}