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The inner retina has been considered the primary region affected in <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>, but choroidal vascular degeneration and progressive outer retinal dysfunctions have also been observed. This review focuses on observations regarding neurovascular dysfunctions in both the inner and outer immature retina, the mechanisms and the neuronal\u2010derived factors implicated in the development of <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>, as well potential therapeutic avenues for this disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Alterations in the neurovascular integrity of the inner and outer retina contribute to the development of <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13586","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T10:32:31Z","timestamp":1473762751000},"page":"1421-1433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Review of the mechanisms and therapeutic avenues for retinal and choroidal vascular dysfunctions in 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