{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:56:20Z","timestamp":1789923380434,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T00:00:00Z","timestamp":1484870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001073"],"award-info":[{"award-number":["UL1TR001073"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study assessed the <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) serum antibody test as a diagnostic screening tool in symptomatic inner city children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of patients aged one to 18 years who were referred to our paediatric gastroenterology department from 2009 to 2013. We included all patients who had <jats:italic>H. pylori<\/jats:italic> serum antibodies and\/or faecal antigens who underwent esophagogastroduodenoscopy (<jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content>) for histology, with or without a gastric tissue rapid urease test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 395 patients had <jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content>s carried out to evaluate epigastric pain, heartburn and nausea or vomiting, and their overall socio\u2010economic <jats:italic>Z<\/jats:italic>\u2010score was \u22122.62. The histology was positive for <jats:italic>H. pylori<\/jats:italic> infection in 52 of 395 patients (13%), and epigastric pain was documented in 45 of these 52 patients (87%). Compared to histology, the serum <jats:italic>H. pylori<\/jats:italic> antibody test had a sensitivity of 88.4% and a specificity of 93.4%. The tissue rapid urease test and faecal antigen test had sensitivities of 89.3% and 55.6% and specificities of 89.9% and 98.9%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The serum <jats:italic>H. pylori<\/jats:italic> antibody test had high sensitivity and specificity, and it was a good diagnostic screening tool in our study. Epigastric pain was strongly associated with a current <jats:italic>H. pylori<\/jats:italic> infection in our population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13724","type":"journal-article","created":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T14:22:51Z","timestamp":1482762171000},"page":"470-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<i>Helicobacter pylori<\/i> serology testing is a useful diagnostic screening tool for symptomatic inner city children"],"prefix":"10.1111","volume":"106","author":[{"given":"Priya","family":"Raj","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Hepatology and Nutrition The Children's Hospital at Montefiore Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Hepatology and Nutrition The Children's Hospital at Montefiore Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra H.","family":"Pan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Hepatology and Nutrition The Children's Hospital at Montefiore Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2008.02.026"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70422-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.159.5.415"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.61"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/1999\/286943"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(02)00459-2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MPG.0000163734.84518.9E"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-009-1033-x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200011000-00007"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182227e90"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.11.037"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.5.1120"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(97)70174-3"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199902000-00012"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31815bc5b3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.10.1328"},{"key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1128\/jcm.32.5.1193-1196.1994","article-title":"Serological detection of Helicobacter pylori antibodies in children and their parents","volume":"32","author":"Best LM","year":"1994","journal-title":"J Clin Microbiol"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31818e039b"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30162.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07683.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2008.00617.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.2.178-a"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2008.00603.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1086\/320148"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200010000-00014"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.13724","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.13724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:22:22Z","timestamp":1696357342000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.13724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,20]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/apa.13724"],"URL":"https:\/\/doi.org\/10.1111\/apa.13724","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,20]]},"assertion":[{"value":"2016-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}