{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T14:10:09Z","timestamp":1749910209686,"version":"3.41.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The effect of a supernumerary X chromosome on bones has not been reported, and this study evaluated bone mineral status and metabolism in nonmosaic triple X syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study comprised 19 girls, with a median age of 10.9\u00a0years, with nonmosaic triple X syndrome and a control group matched for age and body size. We studied ionised and total calcium, phosphate, parathyroid hormone (<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>), 25\u2010hydroxyvitamin D (25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D), 1,25\u2010dihydroxyvitamin D, osteocalcin, bone alkaline phosphatase levels and urinary deoxypyridinoline concentrations. We also measured the phalangeal amplitude\u2010dependent speed of sound (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010SoS) and the bone transmission time (<jats:styled-content style=\"fixed-case\">BTT<\/jats:styled-content>)<jats:italic>Z<\/jats:italic>\u2010scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with nonmosaic triple X syndrome showed significantly reduced<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010SoS (p\u00a0&lt;\u00a00.005) and<jats:styled-content style=\"fixed-case\">BTT<\/jats:styled-content><jats:italic>Z<\/jats:italic>\u2010scores (p\u00a0&lt;\u00a00.0001) compared to the control group, and these results persisted when we divided the sample into prepubertal and pubertal patients (p\u00a0&lt;\u00a00.05). These patients also had significantly reduced ionised calcium (p\u00a0&lt;\u00a00.005) and 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D levels (p\u00a0&lt;\u00a00.005) and higher phosphate (p\u00a0&lt;\u00a00.0001) and<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>(p\u00a0&lt;\u00a00.0001) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Subjects with nonmosaic triple X syndrome exhibited a significant impairment in bone mineral status and metabolism similar to other X polisomy, such as Klinefelter's syndrome. This suggests the presence of a primary bone deficit and the need for regular and close monitoring of these subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13744","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T02:37:36Z","timestamp":1484534256000},"page":"619-626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cross\u2010sectional study shows that impaired bone mineral status and\u00a0metabolism are found in nonmosaic triple X syndrome"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2259-4685","authenticated-orcid":false,"given":"Stefano","family":"Stagi","sequence":"first","affiliation":[{"name":"Department of Health Sciences University of Florence, Anna Meyer Children's University Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariarosaria","family":"Di 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