{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:56:43Z","timestamp":1773331003814,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"IBSA Farmaceutici srl"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>More than 50% of children report apian during venepuncture or intravenous cannulation and using local anaesthetics before needle procedures can lead to different success rates. This study examined how many needle procedures were successful at the first attempt when children received either a warm lidocaine and tetracaine patch or an eutectic mixture of lidocaine and prilocaine (<jats:styled-content style=\"fixed-case\">EMLA<\/jats:styled-content>) cream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted this multicentre randomised controlled trial at three tertiary\u2010level children's hospitals in Italy in 2015. Children aged three to 10 years were enrolled in an emergency department, paediatric day hospital and paediatric ward and randomly allocated to receive a warm lidocaine and tetracaine patch or <jats:styled-content style=\"fixed-case\">EMLA<\/jats:styled-content> cream. The primary outcome was the success rate at the first attempt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 172 children who received a warm lidocaine and tetracaine patch and 167 who received an <jats:styled-content style=\"fixed-case\">EMLA<\/jats:styled-content> cream. The needle procedure was successful at the first attempt in 158 children (92.4%) who received the warm patch and in 142 children (85.0%) who received the cream (p = 0.03). The pain scores were similar in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that the first\u2010time needle procedure success was 7.4% higher in children receiving a warm lidocaine and tetracaine patch than <jats:styled-content style=\"fixed-case\">EMLA<\/jats:styled-content> cream.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13764","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T01:33:04Z","timestamp":1485567184000},"page":"773-778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["First\u2010time success with needle procedures was higher with a warm lidocaine and tetracaine patch than an eutectic mixture of lidocaine and prilocaine cream"],"prefix":"10.1111","volume":"106","author":[{"given":"Giorgio","family":"Cozzi","sequence":"first","affiliation":[{"name":"Institute for Maternal and Child Health IRCCS Burlo Garofolo Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Borrometi","sequence":"additional","affiliation":[{"name":"Pediatric Pain Service and Palliative Care Department of Oncology Pausilipon Hospital AORN Santobono Pausilipon Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franca","family":"Benini","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University of Padua Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Neri","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health IRCCS Burlo Garofolo Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Rusalen","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University of Padua Padua 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