{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:48:41Z","timestamp":1765079321721},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Institut de la M\u00e8re et de L'enfant"},{"name":"University of Hanoi, Vietnam"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study examined the heart rate variability characteristics associated with early\u2010onset neonatal sepsis in a prospective, observational controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible patients were full\u2010term neonates hospitalised with clinical signs that suggested early\u2010onset sepsis and a C\u2010reactive protein of &gt;10 mg\/L. Sepsis was considered proven in cases of symptomatic septicaemia, meningitis, pneumonia or enterocolitis. Heart rate variability parameters (n = 16) were assessed from five\u2010, 15\u2010 and 30\u2010minute stationary sequences automatically selected from electrocardiographic recordings performed at admission and compared with a control group using the U\u2010test with post hoc Benjamini\u2010Yekutieli correction. Stationary sequences corresponded to the periods with the lowest changes of heart rate variability over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 40 full\u2010term infants were enrolled, including 14 with proven sepsis. The mean duration of the cardiac cycle length was lower in the proven sepsis group than in the control group (n = 11), without other significant changes in heart rate variability parameters. These durations, measured in five\u2010minute stationary periods, were 406 (367\u2013433) ms in proven sepsis group versus 507 (463\u2013522) ms in the control group (p &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early\u2010onset neonatal sepsis was associated with a high mean heart rate measured during automatically selected stationary periods.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13782","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T18:32:44Z","timestamp":1487097164000},"page":"749-754","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Early\u2010onset neonatal sepsis is associated with a high heart rate during automatically selected stationary periods"],"prefix":"10.1111","volume":"106","author":[{"given":"Nga","family":"Nguyen","sequence":"first","affiliation":[{"name":"Inserm, U1099 Rennes 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