{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:48:20Z","timestamp":1779914900852,"version":"3.53.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T00:00:00Z","timestamp":1492387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Although birth asphyxia is a major risk factor for neonatal and childhood morbidity and mortality, it has not been investigated much in relation to attention deficit hyperactivity disorder (<jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>). We examined whether birth asphyxia measured by the pH of the blood in the umbilical artery cord was associated with childhood <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A population\u2010based cohort of 295\u00a0687 children born in Finland between 1991 and 2002 was followed until December 31, 2007. <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content> was identified by the International Classification of Diseases, 10th edition, as a diagnosis of hyperkinetic disorder. We examined the risk of <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content> with varying pH values using Cox regression, taking time trends into consideration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When compared to the reference group, a pH value below 7.10 was significantly associated with an increased risk of <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>. The strongest risks were observed among children with a pH value &lt;7.15 and a gestational age of &lt;32\u00a0weeks. The pH value did not contribute much to the risk among children with an Apgar score of 0\u20133.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Birth asphyxia, defined by low pH value, may predict an increased risk of <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content> in childhood. The association between the pH value and <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content> was homogenous when stratified by gestational age and the Apgar score.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13807","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T06:56:56Z","timestamp":1488351416000},"page":"944-952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Birth asphyxia measured by the <scp>pH<\/scp> value of the umbilical cord blood may predict an increased risk of attention deficit hyperactivity disorder"],"prefix":"10.1111","volume":"106","author":[{"given":"Susanne Hvolgaard","family":"Mikkelsen","sequence":"first","affiliation":[{"name":"Department of Public Health Section for General Medical Practice Aarhus University Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"Olsen","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Department of Clinical Medicine Aarhus University Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodil Hammer","family":"Bech","sequence":"additional","affiliation":[{"name":"Department of Public Health Section\u00a0for Epidemiology Aarhus University Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyan","family":"Liew","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Fielding School of Public Health University of California, Los Angeles (UCLA) Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Gissler","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare Helsinki University Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Obel","sequence":"additional","affiliation":[{"name":"Department of Public Health Section for General Medical Practice Aarhus University Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onyebuchi","family":"Arah","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Fielding School of Public Health University of California, Los Angeles (UCLA) Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.6.942"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-012-0135-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2012.01875.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-014-0553-8"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.1893"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-300482"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2003406"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-1279"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1471"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmwh.2005.08.007"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03335.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.01.003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1298"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.10.041"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073816650039"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.03.002"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.297.6640.24"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2007.08.013"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304179"},{"key":"e_1_2_10_21_1","unstructured":"STAKES: Syntym\u00e4rekisterin lomakeuudistus (Data collection reform for the Medical Birth Register iFOjl). 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