{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:15:58Z","timestamp":1790363758033,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T00:00:00Z","timestamp":1491350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","award":["Y920016024"],"award-info":[{"award-number":["Y920016024"]}],"id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["#276523"],"award-info":[{"award-number":["#276523"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["#288220"],"award-info":[{"award-number":["#288220"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Treatment with therapeutic hypothermia has challenged the use of amplitude\u2010integrated electroencephalography in predicting outcomes after perinatal asphyxia. In this study, we assessed the feasibility and gain of somatosensory evoked potentials (<jats:styled-content style=\"fixed-case\">SEP<\/jats:styled-content>) during hypothermia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study comprised neonates from 35\u00a0+\u00a06 to 42\u00a0+\u00a02 gestational weeks and treated for asphyxia or hypoxic\u2010ischaemic encephalopathy at Helsinki University Hospital between 14 February 2007 and 23 December 2009. This period was partly before the introduction of routine therapeutic hypothermia, which enabled us to include normothermic neonates who would these days receive hypothermia treatment. We analysed <jats:styled-content style=\"fixed-case\">SEP<\/jats:styled-content>s from 47 asphyxiated neonates and compared the results between 23 normothermic and 24 hypothermic neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our data showed that hypothermia led to <jats:styled-content style=\"fixed-case\">SEP<\/jats:styled-content> latencies lengthening by a few milliseconds, but the essential gain for predicting outcomes by <jats:styled-content style=\"fixed-case\">SEP<\/jats:styled-content>s was preserved during hypothermia. Of the 24 hypothermic neonates, bilaterally absent <jats:styled-content style=\"fixed-case\">SEP<\/jats:styled-content>s were associated with poor outcome in 2\/2 neonates, normal <jats:styled-content style=\"fixed-case\">SEP<\/jats:styled-content>s were associated with good outcomes in 13\/15 neonates and 5\/7 neonates with unilaterally absent or grossly delayed <jats:styled-content style=\"fixed-case\">SEP<\/jats:styled-content>s had a poor outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicated that <jats:styled-content style=\"fixed-case\">SEP<\/jats:styled-content>s were a reliable tool for evaluating the somatosensory system in asphyxiated neonates in both normothermic and hypothermic conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13813","type":"journal-article","created":{"date-parts":[[2017,3,4]],"date-time":"2017-03-04T10:52:26Z","timestamp":1488624746000},"page":"912-917","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Neonatal somatosensory evoked potentials persist during hypothermia"],"prefix":"10.1111","volume":"106","author":[{"given":"P\u00e4ivi","family":"Nevalainen","sequence":"first","affiliation":[{"name":"Department of Clinical Neurophysiology Children's Hospital HUS Medical Imaging Center University of Helsinki and Helsinki University Hospital (HUH) Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Lauronen","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Children's Hospital HUS Medical Imaging Center University of Helsinki and Helsinki University Hospital (HUH) Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjo","family":"Mets\u00e4ranta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital University of Helsinki and HUH Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuula","family":"L\u00f6nnqvist","sequence":"additional","affiliation":[{"name":"Department of Child Neurology Children's Hospital University of Helsinki and HUH Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eero","family":"Ahtola","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Children's Hospital HUS Medical Imaging Center University of Helsinki and Helsinki University Hospital (HUH) Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sampsa","family":"Vanhatalo","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Children's Hospital HUS Medical Imaging Center University of Helsinki and Helsinki University Hospital (HUH) Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/609813"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.72.1.F34"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.81.1.F19"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01653.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339570"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2938"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12226"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2014.12.011"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.73.2.F75"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1992.tb11471.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-5597(97)00076-2"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.01.024"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.12.009"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0095-5108(18)30404-4","article-title":"Somatosensory\u2010evoked potentials in term neonates with postasphyxial encephalopathy","volume":"20","author":"Vries LS","year":"1993","journal-title":"Clin Perinatol"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.4_Spec_No.393"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.05.036"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(76)90080-8"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2009.06.007"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0b013e31824ac36c"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-014-3470-x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2015.03.001"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.11.062"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(89)80006-3"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-5597(87)90058-X"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-5597(88)90011-1"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(90)90098-5"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-5597(84)90038-8"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540250056013"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(03)00349-3"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(70)90114-8"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.13813","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.13813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T03:15:24Z","timestamp":1696475724000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.13813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,5]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/apa.13813"],"URL":"https:\/\/doi.org\/10.1111\/apa.13813","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,5]]},"assertion":[{"value":"2016-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}