{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:05:01Z","timestamp":1782770701453,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T00:00:00Z","timestamp":1493683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008199","name":"RTI International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine which interventions would have the greatest impact on reducing neonatal mortality in sub\u2010Saharan Africa in 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used <jats:styled-content style=\"fixed-case\">MANDATE<\/jats:styled-content>, a mathematical model, to evaluate scenarios for the impact of available interventions on neonatal deaths from primary causes, including: (i) for birth asphyxia \u2013 obstetric care preventing intrapartum asphyxia, newborn resuscitation and treatment of asphyxiated infants; (ii) for preterm birth \u2013 corticosteroids, oxygen, continuous positive air pressure and surfactant; and, (iii) for serious newborn infection \u2013 clean delivery, chlorhexidine cord care and antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Reductions in infection\u2010related mortality have occurred. Between 80 and 90% of deaths currently occurring from infections and asphyxia can be averted from available interventions, as can 58% of mortality from preterm birth. More than 200 000 neonatal deaths can each be averted from asphyxia, preterm birth and infections. Using available interventions, more than 80% of the neonatal deaths occurring today could be prevented in sub\u2010Saharan Africa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reducing neonatal deaths from asphyxia require improvements in infrastructure and obstetric care to manage maternal conditions such as obstructed labour and preeclampsia. Reducing deaths from preterm birth would also necessitate improved infrastructure and training for preterm infant care. Reducing infection\u2010related mortality requires less infrastructure and lower\u2010level providers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13853","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T21:13:12Z","timestamp":1491253992000},"page":"1286-1295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Interventions to reduce neonatal mortality: a mathematical model to evaluate impact of interventions in sub\u2010Saharan Africa"],"prefix":"10.1111","volume":"106","author":[{"given":"Jennifer B.","family":"Griffin","sequence":"first","affiliation":[{"name":"RTI International Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"McClure","sequence":"additional","affiliation":[{"name":"RTI International Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beena D.","family":"Kamath\u2010Rayne","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie M.","family":"Hepler","sequence":"additional","affiliation":[{"name":"RTI International Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris J.","family":"Rouse","sequence":"additional","affiliation":[{"name":"RTI International Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan H.","family":"Jobe","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61698-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001080"},{"issue":"3","key":"e_1_2_9_4_1","first-page":"CD007754","article-title":"Community\u2010based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes","author":"Lassi ZS","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-10-19"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2012.10.030"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1586160"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.14.139790"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7454.1490"},{"key":"e_1_2_9_10_1","unstructured":"United Nations.World Population Prospects: The 2012 Revision. 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