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This current report presents physiological data from full\u2010term infants with no prenatal exposure to alcohol or maternal smoking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data are from 666 infants from the Northern Plains (North and South Dakota) and South Africa. A standardised protocol assessed cardiorespiratory function during baseline and head\u2010up tilts shortly after birth and at one month of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analyses revealed significant increases in heart rate and decreases in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> from the newborn to one\u2010month time period as well as diminished heart rate responses to head\u2010up tilt in one\u2010month\u2010old infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Safe Passage Study was successful in characterising physiology in a large number of infants at sites known to have elevated risks for <jats:styled-content style=\"fixed-case\">SIDS<\/jats:styled-content>. Results demonstrate that even with low prenatal adverse exposures, there are significant changes in cardiorespiratory function as infants enter the window of increased risk for <jats:styled-content style=\"fixed-case\">SIDS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13873","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T12:36:54Z","timestamp":1492432614000},"page":"1260-1272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cardiorespiratory physiology in the safe passage study: protocol, methods and normative values in unexposed infants"],"prefix":"10.1111","volume":"106","author":[{"given":"Michael M.","family":"Myers","sequence":"first","affiliation":[{"name":"Department of Psychiatry Columbia University Medical Center New York NY USA"},{"name":"Department of Pediatrics Columbia University Medical Center New York NY USA"},{"name":"Division of Developmental Neuroscience New York State Psychiatric Institute New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy J.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Community and Population Health Sciences Sanford Research Sioux Falls SD USA"},{"name":"Department of Pediatrics Sanford School of Medicine University of South Dakota Sioux Falls SD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hein J.","family":"Odendaal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine and Health Science Stellenbosch University Cape Town Western Cape South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"Burd","sequence":"additional","affiliation":[{"name":"University of North Dakota Medical School Grand Forks ND USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoti","family":"Angal","sequence":"additional","affiliation":[{"name":"Community and Population Health Sciences Sanford Research Sioux Falls SD USA"},{"name":"Department of Pediatrics Sanford School of Medicine University of South Dakota Sioux Falls SD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coen","family":"Groenewald","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine and Health Science Stellenbosch University Cape Town Western Cape South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James David","family":"Nugent","sequence":"additional","affiliation":[{"name":"Division of Developmental Neuroscience New York State Psychiatric Institute New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel S.","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Developmental Neuroscience New York State Psychiatric Institute New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph R.","family":"Isler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Columbia University Medical Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim A.","family":"Dukes","sequence":"additional","affiliation":[{"name":"DM\u2010STAT, Inc. 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