{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:34:17Z","timestamp":1771014857418,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T00:00:00Z","timestamp":1497571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Asphyxiated neonates should be resuscitated with air, but it remains unclear if oxygen supplementation is needed in ineffectively ventilated newborn infants. We studied the return of spontaneous circulation (<jats:styled-content style=\"fixed-case\">ROSC<\/jats:styled-content>) with oxygen or air in an experimental model of inadequate ventilation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Asphyxia was induced in 16 newborn piglets until their heart rate was &lt;60 bpm or mean arterial pressure (<jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>) &lt;30 mmHg. During the first 10 minutes of resuscitation, they received one breath per minute of oxygen (n = 8) or air (n = 8). Tidal volume was 7.5 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/kg. If <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content> was &lt;30 mmHg for 15 seconds, closed\u2010chest cardiac massage (<jats:styled-content style=\"fixed-case\">CCCM<\/jats:styled-content>) was performed for 45 seconds. From 10 minutes onward, all piglets received normal ventilation with air. <jats:styled-content style=\"fixed-case\">ROSC<\/jats:styled-content> was defined as a heart rate &gt;150 bpm, <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content> &gt;40 mmHg and no subsequent <jats:styled-content style=\"fixed-case\">CCCM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before resuscitation, the median arterial <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> was 6.73. At 10 minutes, no piglets in the oxygen group needed <jats:styled-content style=\"fixed-case\">CCCM<\/jats:styled-content>, while all did in the air group (p &lt; 0.001). The median time to <jats:styled-content style=\"fixed-case\">ROSC<\/jats:styled-content> was 60 seconds with oxygen and 845 seconds with air (p &lt; 0.001). No brain tissue hyperoxia occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>When ventilation was inadequate, one oxygen breath reduced time to <jats:styled-content style=\"fixed-case\">ROSC<\/jats:styled-content> in piglets with severe metabolic and respiratory acidosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13920","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T02:56:42Z","timestamp":1494989802000},"page":"1556-1563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["One oxygen breath shortened the time to return of spontaneous circulation in severely asphyxiated piglets"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9178-8686","authenticated-orcid":false,"given":"Rikard","family":"Linner","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Anaesthesia and Intensive Care Lund 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