{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:15:26Z","timestamp":1790248526220,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The V\u00e4re Foundation for Pediatric Cancer Research"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Childhood brain tumour survivors have a high risk of endocrine morbidity. This study evaluated the growth, pubertal development and gonadal function in survivors of childhood brain tumours and identified factors associated with the problems we observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The 52 subjects (52% male) were diagnosed in 1983\u20131997 and treated for brain tumours at Tampere University Hospital, Finland. They were followed up at a mean age of 14.2 (3.8\u201328.7) years, a mean of 7.5 (1.5\u201315.1) years after diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that 30 (58%) participants had a lower height standard deviation score at follow\u2010up than at diagnosis and short stature at follow\u2010up was associated with tumour malignancy (p = 0.005), radiotherapy (p = 0.004), chemotherapy (p = 0.024), growth hormone deficiency (p &lt; 0.001), hypogonadism (p = 0.044) and delayed puberty (p = 0.021). We found that five needed sex hormones to induce puberty, one had precocious puberty, 12 (23%) had growth hormone deficiency and eight (22%) of the 36 pubertal or postpubertal patients had hypogonadism. Testicular volume was low in 83% of late or postpubertal male survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Growth impairment, growth hormone deficiency and hypogonadism were common in childhood brain tumour survivors and low testicular volume was also common in male survivors. Lifelong annual follow\u2010up checks are indicated for survivors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13975","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T17:16:34Z","timestamp":1499361394000},"page":"1684-1693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Growth impairment and gonadal axis abnormalities are common in survivors of paediatric brain tumours"],"prefix":"10.1111","volume":"106","author":[{"given":"Sari","family":"Pietil\u00e4","sequence":"first","affiliation":[{"name":"Rinnekoti Foundation Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"M\u00e4kipernaa","sequence":"additional","affiliation":[{"name":"Department of Hematology Cancer Center Helsinki University Hospital Helsinki University Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Maija","family":"Koivisto","sequence":"additional","affiliation":[{"name":"School of Health Sciences University of Tampere Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna L.","family":"Lenko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25176"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nou321"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199708)29:2<86::AID-MPO4>3.0.CO;2-N"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-006-6042-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.7933"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1500329"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031224"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2004.17.1.55"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1350135"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.00779"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880019609033373"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.3.832"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1984.tb09965.x"},{"key":"e_1_2_11_15_1","first-page":"182","article-title":"A simple calculation of the target height","volume":"97","author":"Dommelen P","year":"2012","journal-title":"Arch Dis Child"},{"key":"e_1_2_11_16_1","unstructured":"OjaniemiM..Lapsen normaali ja poikkeava kasvu. 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