{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T08:12:37Z","timestamp":1696061557402},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T00:00:00Z","timestamp":1501632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>It is unclear whether maternal intrapartum antibiotic treatment (<jats:styled-content style=\"fixed-case\">IAT<\/jats:styled-content>) continues to exert a bactericidal effect on common pathogens in neonates. We studied the <jats:italic>in vitro<\/jats:italic> bactericidal effect of <jats:styled-content style=\"fixed-case\">IAT<\/jats:styled-content> on the cord and peripheral venous blood of newborn infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Umbilical cord and peripheral venous blood from newborn infants born at Kaplan Medical Center, Israel, from April to October 2014 were studied for serum bactericidal titres against <jats:italic>Group B Streptococcus<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content><\/jats:italic>) and <jats:italic>Escherichia coli<\/jats:italic> (<jats:italic>E. coli<\/jats:italic>) strains. We studied 60 samples of umbilical cord blood and 18 samples of peripheral venous blood from 60 newborn infants whose mothers received <jats:styled-content style=\"fixed-case\">IAT<\/jats:styled-content>. The controls were 10 samples of cord blood from mothers without <jats:styled-content style=\"fixed-case\">IAT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cord blood exerted a bactericidal effect against 98% of <jats:italic><jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content><\/jats:italic> isolates but only 8% of <jats:italic>E.coli<\/jats:italic> isolates. Peripheral blood exerted a bactericidal effect against <jats:italic><jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content><\/jats:italic> in 94% of cases, but not against <jats:italic>E. coli<\/jats:italic>. No bactericidal effect was seen in the blood from the controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found a continued bactericidal effect of umbilical cord blood and neonatal peripheral blood from newborn infants of <jats:styled-content style=\"fixed-case\">IAT<\/jats:styled-content>\u2010treated mothers, mainly against <jats:italic><jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content><\/jats:italic>, but rarely against <jats:italic>E. Coli<\/jats:italic>. These findings may assist clinicians treating at\u2010risk infants exposed to <jats:styled-content style=\"fixed-case\">IAT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13982","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T08:36:42Z","timestamp":1499762202000},"page":"1767-1771","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Maternal intrapartum antibiotic treatment continues to exert a bactericidal effect on the umbilical cord and peripheral venous blood of newborn infants"],"prefix":"10.1111","volume":"106","author":[{"given":"C","family":"Hershkovich\u2013Shporen","sequence":"first","affiliation":[{"name":"Department of Neonatology Kaplan Medical Center, Rehovot Hebrew University Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Bardenstein","sequence":"additional","affiliation":[{"name":"Department of Microbiology Kaplan Medical Center, Rehovot Hebrew University Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Blickstein","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kaplan Medical Center, Rehovot Hebrew University Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E S","family":"Shinwell","sequence":"additional","affiliation":[{"name":"Department of Neonatology Ziv Medical Center, Tsfat Faculty of Medicine in the Galil Bar\u2010Ilan University Ramat Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Flidel\u2010Rimon","sequence":"additional","affiliation":[{"name":"Department of Neonatology Kaplan Medical Center, Rehovot Hebrew University Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182238c31"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318219229b"},{"key":"e_1_2_10_4_1","first-page":"149","article-title":"Antibiotic therapy in neonates whose mothers have received intrapartum group B streptococcal chemoprophylaxis","volume":"9","author":"Baker C","year":"1990","journal-title":"Pediatr Infect Dis J"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1996.02170330028005"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7200124"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.85.3.F182"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.3.523"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2006.00980.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.020651-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0255-0857(21)02537-8","article-title":"Incubation period for culture positivity to detect septicemia in neonates","volume":"23","author":"Vinod Kumar CS","year":"2005","journal-title":"Indian J Med Microbiol"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.10.89"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00043-09"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056131"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.03.002"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.5.4.420"},{"key":"e_1_2_10_17_1","volume-title":"Blood cultures 4. Cumitech, cumulative techniques and procedures in clinical biology","author":"Baron EJ","year":"2005"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2001.tb00516.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)80035-4"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(02)00480-7"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1542\/peds.2011-1466","article-title":"Policy statement\u2010recommendations for the prevention of perinatal group B streptococcal (GBS) disease, committee on infectious diseases: Committee on fetus and newborn","volume":"128","author":"Baker CJ","year":"2011","journal-title":"Pediatrics"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.13982","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.13982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T18:57:24Z","timestamp":1696013844000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.13982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,2]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/apa.13982"],"URL":"https:\/\/doi.org\/10.1111\/apa.13982","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,2]]},"assertion":[{"value":"2016-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}