{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T17:06:40Z","timestamp":1784394400390,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T00:00:00Z","timestamp":1503360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study investigated the association between hypothermia and respiratory distress syndrome (<jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content>), bronchopulmonary dysplasia (<jats:styled-content style=\"fixed-case\">BPD<\/jats:styled-content>) or death in very preterm infants admitted to a Danish neonatal intensive care unit (<jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 675 infants born at Aalborg University Hospital before 32 weeks and admitted to the <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> from April 1997 to December 2011. Hypothermia was defined as a core temperature of &lt;36.5\u00b0C on admission. The primary outcome was severe <jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content> or death within the first three days of life, and the secondary outcome was <jats:styled-content style=\"fixed-case\">BPD<\/jats:styled-content> or death before 36 postmenstrual weeks. The multivariable logistic regression was adjusted for early\u2010onset infection, gestational age, Apgar score, sex, treatment year and birth weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Infants with hypothermia had a twofold increase (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) in the odds for <jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content> or death (2.03), but the adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> was not statistically significant (1.36). They also demonstrated a twofold increase (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) in the odds for <jats:styled-content style=\"fixed-case\">BPD<\/jats:styled-content> or death (2.28), but again the adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> was not statistically significant (1.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After adjusting for confounders, we found that the association between hypothermia on admission to the <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content> or death, or <jats:styled-content style=\"fixed-case\">BPD<\/jats:styled-content> or death was statistically insignificant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.13998","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T14:32:42Z","timestamp":1500647562000},"page":"1934-1939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Hypothermia at neonatal intensive care unit admission was not associated with respiratory disease or death in very preterm infants"],"prefix":"10.1111","volume":"106","author":[{"given":"CF","family":"Jensen","sequence":"first","affiliation":[{"name":"Perinatal Epidemiology Research Unit Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Ebbesen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JP","family":"Petersen","sequence":"additional","affiliation":[{"name":"Perinatal Epidemiology Research Unit Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Pediatrics Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Sellmer","sequence":"additional","affiliation":[{"name":"Perinatal Epidemiology Research Unit Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Pediatrics Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CC","family":"Bach","sequence":"additional","affiliation":[{"name":"Perinatal Epidemiology Research Unit Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Pediatrics Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TB","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Perinatal Epidemiology Research Unit Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Pediatrics Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0943"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.0277"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.177"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.4.659"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/49.2.115"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131976"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1542\/peds.22.5.876","article-title":"The influence of the thermal environment upon the survival of newly born premature infants","volume":"22","author":"Silverman WA","year":"1958","journal-title":"Pediatrics"},{"key":"e_1_2_11_9_1","first-page":"258","article-title":"Importance of pre\u2010 and perinatal risk factors in respiratory distress syndrome of premature infants. 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