{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:23:52Z","timestamp":1776842632490,"version":"3.51.2"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,13]],"date-time":"2017-08-13T00:00:00Z","timestamp":1502582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00d6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Interleukin\u201017 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017) appears to promote the host's defence against mycobacterial infections. This study evaluated the association between <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A<\/jats:italic> gene polymorphism and the risk of Bacillus Calmette\u2010Gu\u00e9rin (<jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>) osteitis after newborn vaccination and between <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A<\/jats:italic> gene polymorphism and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A concentrations in serum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A<\/jats:italic> rs2275913 gene polymorphisms and serum <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A<\/jats:italic> concentrations were studied in 132 adults aged 21\u201349 years from across Finland, who had <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> osteitis in infancy after a newborn <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> vaccination. The subjects were recruited in 2007\u20132008, and their whole\u2010blood samples were sent to the National Institute for Health and Welfare, Turku, Finland. Their genotypes and minor allele frequencies were compared with 405 population\u2010based unvaccinated controls aged two to three months from a prospective birth cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The genotypes and allele frequencies of <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A<\/jats:italic> rs2275913 differed significantly between the former <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> osteitis patients and controls. The genotype was variant in 75.8% of cases and 64.0% of controls (p = 0.012), and the minor allele frequency was 50.0% in the cases and 41.6% of the controls (p = 0.009). Serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 concentrations did not differ significantly between the cases with wild or variant genotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A<\/jats:italic> rs2275913 gene polymorphism was associated with a risk of <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> osteitis after vaccination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14000","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T14:36:39Z","timestamp":1500647799000},"page":"1837-1841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<i>Interleukin 17A<\/i> gene polymorphism rs2275913 is associated with osteitis after the Bacillus Calmette\u2010Gu\u00e9rin vaccination"],"prefix":"10.1111","volume":"106","author":[{"given":"Milla","family":"Liehu\u2010Martiskainen","sequence":"first","affiliation":[{"name":"Center for Child Health Research Faculty of Medicine and Life Sciences University of Tampere and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Korppi","sequence":"additional","affiliation":[{"name":"Center for Child Health Research Faculty of Medicine and Life Sciences University of Tampere and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Ter\u00e4sj\u00e4rvi","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juho","family":"Vuononvirta","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heini","family":"Huhtala","sequence":"additional","affiliation":[{"name":"School of Health Sciences Faculty of Social Sciences University of Tampere Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsi","family":"Nuolivirta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sein\u00e4joki Central Hospital Sein\u00e4joki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liisa","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ville","family":"Peltola","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Turku and University Hospital Turku 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