{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:47:36Z","timestamp":1783057656412,"version":"3.54.6"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study evaluated the incidence and risk factors for intensive care and respiratory support in infant bronchiolitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective descriptive case\u2013control study focused on 105 patients treated in the paediatric intensive care unit (<jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content>) and 210 controls treated in the emergency department or on the paediatric ward in Tampere University Hospital in Finland between 2000 and 2015. Statistically significant risk factors in nonadjusted analyses were included in the adjusted logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average age\u2010specific annual incidence of bronchiolitis requiring <jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content> admission under the age of 12 months was 1.5\/1000\/year (range 0.18\u20132.59). Independently, significant risk factors for <jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content> admission were as follows: being less than two months old with an adjusted odds ratio (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>) of 11.5, birthweight of &lt;2000 g (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> of 15.9), congenital heart disease (CHD) (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> of 15.9), apnoea (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> of 7.2) and the absence of wheezing (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> of 2.2). Significant risk factors for needing respiratory support were a birthweight of &lt;2000 g, an age of less than two months and CHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Less than 0.1% of infants under the age of 12 months were admitted to the <jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content> for bronchiolitis. Low age, low birthweight or prematurity and CHD were independently significant risk factors for both intensive care and respiratory support.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14021","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T07:52:42Z","timestamp":1502437962000},"page":"2004-2010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Low age, low birthweight and congenital heart disease are risk factors for intensive care in infants with bronchiolitis"],"prefix":"10.1111","volume":"106","author":[{"given":"Minna","family":"Mecklin","sequence":"first","affiliation":[{"name":"Tampere Center for Child Health Research University of Tampere and Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Heikkil\u00e4","sequence":"additional","affiliation":[{"name":"Tampere Center for Child Health Research 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