{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:03:24Z","timestamp":1788458604639,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T00:00:00Z","timestamp":1505865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP7 project 305485 PREVENT\u2013ROP"],"award-info":[{"award-number":["FP7 project 305485 PREVENT\u2013ROP"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study evaluated poor weight gain as a risk factor for infants who required treatment for retinopathy of prematurity (<jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>), by comparing those born before and after the implementation of higher oxygen saturation (SpO<jats:sub>2<\/jats:sub>) targets at the Queen Silvia Children's Hospital, Gothenburg, Sweden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared infants born at less than 31 weeks, who were screened and, or, treated for <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>: 127 in 2011\u20132012 when SpO<jats:sub>2<\/jats:sub> targets were 88\u201392% and 142 in 2015\u20132016 when they were 91\u201395%. The subjects were reviewed for birth characteristics, weekly weight and <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> treatment. Data were analysed using the weight, insulin\u2010like growth factor 1, neonatal, <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">WINROP<\/jats:styled-content>) prediction tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 2011\u20132012 infants who needed <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> treatment (12.6%) had significantly poorer postnatal weight gain than those who did not, but this was not seen in the treated (17.6%) and nontreated <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> groups in 2015\u20132016. <jats:styled-content style=\"fixed-case\">WINROP<\/jats:styled-content> sensitivity decreased from 87.5% in 2011\u201312 to 48% in 2015\u20132016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After the SpO<jats:sub>2<\/jats:sub> target range was increased from 88\u201392% to 91\u201395%, postnatal weight gain was no longer a significant risk factor and <jats:styled-content style=\"fixed-case\">WINROP<\/jats:styled-content> lost its ability\u00a0to\u00a0predict <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> requiring treatment. Risk factors clearly change as neonatal care develops.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14049","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T11:18:33Z","timestamp":1504610313000},"page":"767-773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Implementing higher oxygen saturation targets reduced the impact of poor weight gain as a predictor for retinopathy of prematurity"],"prefix":"10.1111","volume":"107","author":[{"given":"Pia","family":"Lundgren","sequence":"first","affiliation":[{"name":"Section\u00a0for Ophthalmology Department of Clinical Neuroscience Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2013Lena","family":"H\u00e5rd","sequence":"additional","affiliation":[{"name":"Section\u00a0for Ophthalmology Department of Clinical Neuroscience Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa","family":"Wilde","sequence":"additional","affiliation":[{"name":"Section\u00a0for Ophthalmology Department of Clinical Neuroscience Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chatarina","family":"L\u00f6fqvist","sequence":"additional","affiliation":[{"name":"Section\u00a0for Ophthalmology Department of Clinical Neuroscience Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois E. H.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Harvard Medical School Boston Children's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[{"name":"Section\u00a0for Ophthalmology Department of Clinical Neuroscience Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.205"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0022-3476(60)80083-2","article-title":"Recent increase in mortality from hyaline membrane disease","volume":"1960","author":"Avery ME","year":"1960","journal-title":"J Pediatr"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1964.tb10800.x"},{"issue":"4","key":"e_1_2_11_5_1","first-page":"Cd011190","article-title":"Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants","author":"Askie LM","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2697"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012872"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2012.243"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.69"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2012.215"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.12.1711"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1136\/bjophthalmol-2014-304905","article-title":"Weight at first detection of retinopathy of prematurity predicts disease severity","volume":"98","author":"Lundgren P","year":"2014","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1001\/archopht.121.12.1684","article-title":"Revised indications for the treatment of retinopathy of prematurity","volume":"121","author":"Group Etfropc","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14164.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073256"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.10.005"},{"key":"e_1_2_11_18_1","first-page":"78","article-title":"A physiologic reduced oxygen protocol decreases the incidence of threshold retinopathy of prematurity","volume":"104","author":"Wright KW","year":"2006","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0413"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3099"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0117"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199204163261603"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.3307"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2218"},{"key":"e_1_2_11_25_1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/pr.2016.98","article-title":"Graded oxygen saturation targets and retinopathy of prematurity in extremely preterm infants","volume":"80","author":"Cayabyab R","year":"2016","journal-title":"Pediatr Res"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000454917"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.14049","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.14049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:30:36Z","timestamp":1695555036000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.14049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,20]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/apa.14049"],"URL":"https:\/\/doi.org\/10.1111\/apa.14049","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,20]]},"assertion":[{"value":"2017-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}