{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:32:24Z","timestamp":1767983544544,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We studied the functional polymorphisms of intercellular adhesion molecule\u20101 (ICAM\u20101) and toll\u2010like receptor\u20104 (TLR\u20104) genes and risk of acute pyelonephritis (APN) in children attending Assiut University Children's Hospitals, Egypt, from 2011 to 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Urinary tract infections (<jats:styled-content style=\"fixed-case\">UTI<\/jats:styled-content>s) were diagnosed in 380 children: 98 had APN and 282 had lower <jats:styled-content style=\"fixed-case\">UTI<\/jats:styled-content>s. Four single\u2010nucleotide polymorphisms in ICAM\u20101 and TLR\u20104 genes were genotyped in all subjects: <jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101 rs1799969 Gly241Arg, <jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101 rs5498 Glu469Lys, <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>\u20104 rs4896791 Thr399Ile and <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>\u20104 rs4896790 Asp299Gly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with APN were significantly more likely to have <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> genotype of the <jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101 rs5498 (1462 A\/G) polymorphism (p\u00a0=\u00a00.04) than children with lower <jats:styled-content style=\"fixed-case\">UTI<\/jats:styled-content>s and the <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>\u20104 Asp299Gly <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype (p\u00a0=\u00a00.002) and G allele (p\u00a0=\u00a00.006) than healthy controls. The association with the <jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101 Glu469Lys (1462A\/G) was less evident. The <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype was associated with a modest relative risk of 1.4 (p\u00a0=\u00a00.1) of developing APN, but was not an independent odds ratio, at 1.2 (p\u00a0=\u00a00.48).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Functional variants in ICAM\u20101 and TLR\u20104 genes were increasingly common in children with febrile <jats:styled-content style=\"fixed-case\">UTI<\/jats:styled-content>s with renal parenchymal involvement, but the <jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101 Glu469Lys (1462A\/G) association was less evident. <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4 Asp299Gly might independently increase renal parenchymal infection rather than renal scarring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14118","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T16:16:38Z","timestamp":1507911398000},"page":"339-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Functional variants in intercellular adhesion molecule\u20101 and toll\u2010like receptor\u20104 genes are more frequent in children with febrile urinary tract infection with renal parenchymal involvement"],"prefix":"10.1111","volume":"107","author":[{"given":"Almontaser","family":"Hussein","sequence":"first","affiliation":[{"name":"Children Hospital Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Saad","sequence":"additional","affiliation":[{"name":"Children Hospital Assiut University Assiut 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