{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:54:41Z","timestamp":1793314481231,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1045559"],"award-info":[{"award-number":["APP1045559"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the effects of foetal growth restriction (<jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>) and prematurity on cardiac morphology and function in infancy. We hypothesised that <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> and prematurity would both alter cardiac development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cardiac morphology and function were evaluated in 24 preterm <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> infants (p\u2010<jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>) and 23 preterm and 19 term appropriately grown for gestational age infants (p\u2010<jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> and t\u2010<jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>, respectively) by conventional echocardiography and Tissue Doppler Imaging. p\u2010<jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> and p\u2010<jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> infants were studied on postnatal day 1 and all groups were studied at one\u2010and six\u2010months post\u2010term age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>p\u2010<jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> infants demonstrated increased cardiac sphericity compared to <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> peers on postnatal day 1 (p\u00a0=\u00a00.004) and at one\u2010month post\u2010term age (p\u00a0=\u00a00.004). Posterior and relative wall thickness increased overtime in the p\u2010<jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> group only (p\u00a0&lt;\u00a00.05). Systolic function was not different between groups. E\/e\u2019 ratio was higher in both preterm groups compared to the term group at one\u2010month post\u2010term age (p\u00a0=\u00a00.01). No statistically significant group differences were found at six\u2010months post\u2010term age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Foetal growth restriction was associated with subtle cardiac morphological changes, whereas both prematurity and <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> were associated with subclinical alterations in diastolic function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14144","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T12:52:41Z","timestamp":1510145561000},"page":"450-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Effects of foetal growth restriction and preterm birth on cardiac morphology and function during infancy"],"prefix":"10.1111","volume":"107","author":[{"given":"Emily","family":"Cohen","sequence":"first","affiliation":[{"name":"The Ritchie Centre Hudson Institute of Medical Research and Department of Paediatrics Monash University Melbourne Vic. Australia"},{"name":"Department of Neonatology Wilhelmina Children's Hospital Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie","family":"Whatley","sequence":"additional","affiliation":[{"name":"Monash Heart Monash Health Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora Y.","family":"Wong","sequence":"additional","affiliation":[{"name":"The Ritchie Centre Hudson Institute of Medical Research and Department of Paediatrics Monash University Melbourne Vic. Australia"},{"name":"Monash Newborn Monash Children's Hospital Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euan M.","family":"Wallace","sequence":"additional","affiliation":[{"name":"The Ritchie Centre Department of Obstetrics and Gynaecology Monash University Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne C.","family":"Mockler","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Monash Health Monash University and Monash Women's Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexsandria","family":"Odoi","sequence":"additional","affiliation":[{"name":"The Ritchie Centre Hudson Institute of Medical Research and Department of Paediatrics Monash University Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Hollis","sequence":"additional","affiliation":[{"name":"The Ritchie Centre Hudson Institute of Medical Research and Department of Paediatrics Monash University Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary S. 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