{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:44:33Z","timestamp":1784630673516,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["PPD460004"],"award-info":[{"award-number":["PPD460004"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We investigated the association between active hypothermia and hypocapnia in neonates with moderate\u2010to\u2010severe hypoxic\u2010ischaemic encephalopathy (<jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content>) transported after birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study of neonates with <jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content> born between 2007 and 2011 and transported to Semmelweis University, Hungary, for hypothermia treatment before and after we introduced active cooling during transport in 2009. Of these, 71 received intensive care plus controlled active hypothermia during transport, while the 46 controls just received standard intensive care. Incident hypocapnia was defined as a partial pressure of carbon\u2010dioxide (pCO<jats:sub>2<\/jats:sub>) that decreased below 35 mm Hg during transport. Multivariable logistic regression investigated the relationship between hypothermia and incident hypocapnia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Incident hypocapnia was more frequent in the actively cooled transport group (36.6%) than control group (17.4%; p = 0.025). pCO<jats:sub>2<\/jats:sub> decreased from a median of 45 to 35 mm Hg (p &lt; 0.0001) in the intervention group, but remained unchanged in the controls. After adjusting for confounders, hypothermia remained an independent risk factor for hypocapnia with an odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) of 4.23 and 95% confidence interval (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) of 1.30\u201313.79. Sedation was associated with a reduction in <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> of hypocapnia, at 0.35 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.12\u20130.98).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hypothermia increased the risk of hypocapnia in neonates with <jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content> during transport.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14159","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T16:13:00Z","timestamp":1511539980000},"page":"1902-1908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Asphyxiated neonates who received active therapeutic hypothermia during transport had higher rates of hypocapnia than controls"],"prefix":"10.1111","volume":"107","author":[{"given":"Eniko","family":"Szakmar","sequence":"first","affiliation":[{"name":"1st Department of Paediatrics Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kata","family":"Kovacs","sequence":"additional","affiliation":[{"name":"1st Department of Paediatrics Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unoke","family":"Meder","sequence":"additional","affiliation":[{"name":"1st Department of Paediatrics Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geza","family":"Bokodi","sequence":"additional","affiliation":[{"name":"1st Department of Paediatrics Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Szell","sequence":"additional","affiliation":[{"name":"Neonatal Emergency &amp; Transport Services of the Peter Cerny Foundation Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Somogyvari","sequence":"additional","affiliation":[{"name":"Neonatal Emergency &amp; Transport Services of the Peter Cerny Foundation Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila J.","family":"Szabo","sequence":"additional","affiliation":[{"name":"1st Department of Paediatrics Semmelweis University Budapest Hungary"},{"name":"Paediatrics and Nephrology Research Group MTA\u2010SE Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miklos","family":"Szabo","sequence":"additional","affiliation":[{"name":"1st Department of Paediatrics Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Jermendy","sequence":"additional","affiliation":[{"name":"1st Department of Paediatrics Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71048-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.05.010"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c363"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.674481"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119153"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353948"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2009.168"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2010.03.006"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.62"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.10.019"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.048785"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3174"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900854"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/29.11.1877"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1955"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/clinchem\/43.1.215","article-title":"Evaluation of the newborn's blood gas status. 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