{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:38:49Z","timestamp":1777563529830,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","award":["2006\u20103858"],"award-info":[{"award-number":["2006\u20103858"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","award":["2009\u20104250"],"award-info":[{"award-number":["2009\u20104250"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010305","name":"Bernadotte Foundation For Children\u2019s Eyecare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002514","name":"Korea Military Academy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002514","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010810","name":"\u00d6gonfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study evaluated the contributions of various prenatal and postnatal predictive factors to a documented high prevalence of ophthalmological abnormalities in children aged 6.5 years who were born extremely preterm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We carried out a prospective population\u2010based study of all children born in Sweden at a gestational age of 22\u00a0+\u00a00 to 26\u00a0+\u00a06\u00a0weeks based on the Extremely Preterm Infants in Sweden Study. The main outcome measures were a combined score of visual impairment, refractive errors and strabismus at 6.5\u00a0years of age. Models of univariate and multivariable regression were used to analyse potential prenatal and postnatal predictive factors at different clinically relevant time\u2010points from one minute after birth to 30\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We focused on 399 known extremely preterm survivors and compared them to 300 full\u2010term controls. Significant antecedents for ophthalmological abnormalities included prematurity <jats:italic>per se<\/jats:italic>, retinopathy of prematurity that required treatment, severe bronchopulmonary dysplasia and cerebral palsy. Severe intraventricular haemorrhage was no longer a significant risk factor when we adjusted it for the 30\u2010month cognitive and neuromotor development outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This time\u2010course risk analysis model showed a changing panorama of significant risk factors for ophthalmological abnormalities in children aged 6.5\u00a0years who were born extremely preterm.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14206","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T19:03:29Z","timestamp":1514401409000},"page":"811-821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Extreme prematurity, treated retinopathy, bronchopulmonary dysplasia and cerebral palsy are significant risk factors for ophthalmological abnormalities at 6.5\u00a0years of age"],"prefix":"10.1111","volume":"107","author":[{"given":"Ann","family":"Hellstr\u00f6m","sequence":"first","affiliation":[{"name":"Section\u00a0of Pediatric Ophthalmology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"K\u00e4ll\u00e9n","sequence":"additional","affiliation":[{"name":"Centre of Reproductive Epidemiology Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitta","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Holmstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Ophthalmology University Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Jakobsson","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia","family":"Lundgren","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Ophthalmology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredrik","family":"Serenius","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Section\u00a0for Pediatrics Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Stjernqvist","sequence":"additional","affiliation":[{"name":"Department of Psychology Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Tornqvist","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Lund University Hospital Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Hellgren","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60136-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2016.0391"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2014.03.007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073815599258"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.771"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01846.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.244"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.3786"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.5812"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.1210"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12726"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.01.052"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.04.027"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2009.263"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143248"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30732"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00855.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1082"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041367"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/08035250600599727"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0372"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-311228"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.9.1124"},{"key":"e_1_2_11_25_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jaapos.2012.10.025","article-title":"Progression of myopia and high myopia in the Early Treatment for Retinopathy of Prematurity study: findings at 4 to 6\u00a0years of age","volume":"17","author":"Quinn GE","year":"2013","journal-title":"J AAPOS"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2010.72"},{"key":"e_1_2_11_27_1","first-page":"536","article-title":"Prevalence and course of strabismus through age 6\u00a0years in participants of the Early Treatment for Retinopathy of Prematurity randomized trial","volume":"15","author":"VanderVeen DK","year":"2011","journal-title":"J\u00a0AAPOS"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2007.08.012"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1997.tb07405.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000101344"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.07.067"},{"key":"e_1_2_11_32_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jaapos.2014.01.014","article-title":"Retinopathy of prematurity and brain damage in the very preterm newborn","volume":"18","author":"Allred EN","year":"2014","journal-title":"J AAPOS"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.14206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.14206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:31:24Z","timestamp":1695555084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.14206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,18]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/apa.14206"],"URL":"https:\/\/doi.org\/10.1111\/apa.14206","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,18]]},"assertion":[{"value":"2017-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}