{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:07:02Z","timestamp":1790719622427,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This Italian study evaluated whether painful procedures during the first four weeks of life were related to subsequent weight gain, head circumference (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>) and neurodevelopmental outcomes in preterm infants,<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the number of invasive procedures that infants born at less than 32\u00a0weeks of gestational age (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>) underwent in the Neonatal Intensive Care Unit of Careggi Hospital, Florence, from January to December 2015. Weight and <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> were recorded at birth, 36\u00a0weeks of <jats:styled-content style=\"fixed-case\">PMA<\/jats:styled-content> and six and 12\u00a0months of <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>. Neurological outcomes were assessed at six and 12\u00a0months of <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> using the Bayley Scales of Infant and Toddler Development \u2013 Third Edition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We studied 83 preterm infants with a <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> of 28\u00a0\u00b1\u00a02\u00a0weeks and birth weight of 1098\u00a0\u00b1\u00a0340\u00a0g. A higher number of invasive painful procedures were related to a lower <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> standard deviation score at 36\u00a0weeks of <jats:styled-content style=\"fixed-case\">PMA<\/jats:styled-content> and six and 12\u00a0months of <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> and with lower cognitive scores at six months. At 12\u00a0months, the relationship only remained significant for infants born at less than 28\u00a0weeks (p\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Invasive painful procedures affected regular <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> growth and short\u2010term cognitive scores in preterm infants in the first year of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14222","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T15:09:23Z","timestamp":1516201763000},"page":"784-790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Painful procedures can affect post\u2010natal growth and neurodevelopment in preterm infants"],"prefix":"10.1111","volume":"107","author":[{"given":"Caterina","family":"Coviello","sequence":"first","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Popple Martinez","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Drovandi","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iuri","family":"Corsini","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Lunardi","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Neurology Unit A. Meyer Children's Hospital of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Pratesi","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Dani","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"},{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health Careggi University Hospital of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.2.280"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2001.004044"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0062683","article-title":"EPIPAGE Study Group. 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