{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:35:42Z","timestamp":1773786942614,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T00:00:00Z","timestamp":1518998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study evaluated the epidemiology and performance of biomarkers for identifying bacterial infections in children who presented with fever without source.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective cohort study in the paediatric department at the University Hospital of Nantes, France, in 2016. Children older than six days and younger than five years of age were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1060 children (52.2% male) with fever without source were admitted, and the median age was 17\u00a0months (interquartile range: 6.6\u201324.3\u00a0months). Severe bacterial infections were diagnosed in 127 (11.9%) children and invasive bacterial infections in 11 (1.0%) children: four (0.3%) with bacterial meningitis and seven (0.6%) with bacteraemia. A further 114 (10.7%) had urinary tract infections. We explored the area under the receiver\u2010operating characteristic curves for identifying invasive bacterial infections. The curves for procalcitonin and C\u2010reactive protein assays were better than those for the absolute neutrophil counts and the white blood cell counts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study found that there was a low prevalence of invasive bacterial infections in children who presented with fever without source. It also showed that procalcitonin and C\u2010reactive protein may help to detect invasive bacterial infections in children who have fever without source.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14248","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T23:42:45Z","timestamp":1517442165000},"page":"1262-1269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Procalcitonin and C\u2010reactive protein may help to detect invasive bacterial infections in children who have fever without source"],"prefix":"10.1111","volume":"107","author":[{"given":"Ga\u00eblle","family":"Hubert\u2010Dibon","sequence":"first","affiliation":[{"name":"Pediatrics Emergency Department University Hospital Nantes Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lou","family":"Danjou","sequence":"additional","affiliation":[{"name":"Pediatrics Emergency Department University Hospital Nantes Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Feildel\u2010Fournial","sequence":"additional","affiliation":[{"name":"Pediatrics Emergency Department University Hospital Nantes Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9n\u00e9dicte","family":"Vrignaud","sequence":"additional","affiliation":[{"name":"Pediatrics Emergency Department University Hospital Nantes Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Masson","sequence":"additional","affiliation":[{"name":"Biochemistry Laboratory UMR INSERM 1235 University Hospital of Nantes Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Launay","sequence":"additional","affiliation":[{"name":"Pediatrics Emergency Department University Hospital Nantes Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christ\u00e8le","family":"Gras\u2010Le Guen","sequence":"additional","affiliation":[{"name":"Pediatrics Emergency Department University Hospital Nantes Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1594"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.2.311"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.03.047"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.08.042"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2061"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.3210"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3575"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2014.07.034"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/acem.12316"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-4381"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318168d2b4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.176800"},{"key":"e_1_2_10_14_1","unstructured":"National Institute for Health and Care Excellence.Feverish illness in children: Assessment and initial management in children younger than 5\u00a0years. 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