{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T15:27:36Z","timestamp":1759073256906,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009336","name":"Bengt Ihres Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to validate the Rome <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> criteria and alarm symptoms with regard to their ability to discriminate between organic and functional diagnoses in children with gastrointestinal complaints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 258 children aged four years to 17 years who consulted a paediatrician in secondary or tertiary care in Stockholm from January 2013 to May 2014 due to gastrointestinal complaints. A symptom questionnaire based on the official Questionnaire on Pediatric Gastrointestinal Symptoms Rome <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, including questions on alarm symptoms, was used. A diagnostic review of their medical records was also carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The reference diagnoses were organic (16%), pain\u2010predominant functional gastrointestinal disorders (54%) and other functional diseases (30%). When the reported symptoms that fulfilled the Rome <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> criteria for pain\u2010predominant functional gastrointestinal disorders were combined with an absence of alarm symptoms, they had a high specificity (0.90) for a functional diagnosis, but a low sensitivity (0.15). Alarm symptoms were equally common in patients with organic (83%) and functional diseases (80%, p = 0.66).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combining the Rome <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> criteria and an absence of alarm symptoms from patient questionnaires had high specificity but low sensitivity when diagnosing pain\u2010predominant functional gastrointestinal disorders in children seeking medical care for gastrointestinal complaints.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14297","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T18:38:58Z","timestamp":1519756738000},"page":"1635-1641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Combining Rome <scp>III<\/scp> criteria with alarm symptoms provides high specificity but low sensitivity for functional gastrointestinal disorders in children"],"prefix":"10.1111","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6484-8789","authenticated-orcid":false,"given":"Agneta","family":"Uusij\u00e4rvi","sequence":"first","affiliation":[{"name":"Astrid Lindgren Children's Hospital Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset, Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola","family":"Ol\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset, Karolinska Institutet Stockholm Sweden"},{"name":"Sachs\u2019 Children's Hospital Stockholm Sweden"},{"name":"Clinical Epidemiology Unit Department of Medicine Solna Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petter","family":"Malmborg","sequence":"additional","affiliation":[{"name":"Sachs\u2019 Children's 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