{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:50:40Z","timestamp":1790923840779,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000008","name":"Packard Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000008","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify neonates at risk of haemolytic hyperbilirubinaemia through near\u2010concurrent measurements of total serum\/plasma bilirubin (TB) or transcutaneous bilirubin (TcB) and end\u2010tidal breath carbon monoxide (CO), corrected for ambient CO (ETCOc), an index of bilirubin production and haemolysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Paired TB\/TcB (mg\/dL) and ETCOc (ppm) measurements were obtained in newborns (n = 283) at 20 to &lt;60 hours of age in five nurseries. TB\/TcB values were assigned TB\/TcB percentile risk values using the Bhutani hour\u2010specific nomogram. In infants having two serial TB\/TcB measurements (n = 76), TB rate of rise (ROR, mg\/dL\/h) was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the entire cohort (n = 283), 67.1% and 32.9% had TB\/TcB&lt;75th and \u226575th percentile, respectively. TB\/TcB (5.79 \u00b1 1.84 vs 9.14 \u00b1 2.25 mg\/dL) and ETCOc (1.61 \u00b1 0.45 vs 2.02 \u00b1 1.35 ppm, p = 0.0002) were different between the groups. About 36.6% of infants with TB\/TcB \u226575th percentile had ETCOc \u2265 2.0 ppm. In the subcohort of infants with serial TB\/TcB measurements (n = 76), 44.7% and 55.3% had TB\/TcB&lt;75th and \u226575th percentile, respectively. TB\/TcB (5.28 \u00b1 1.97 vs 9.53 \u00b1 2.78 mg\/dL), ETCOc (1.72 \u00b1 0.48 vs 2.38 \u00b1 1.89 ppm, p = 0.05) and TB ROR (0.011 \u00b1 0.440 vs 0.172 \u00b1 0.471 mg\/dL\/h) were different between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combined use of TB\/TcB percentile risk assessments and ETCOc measurements can identify infants with haemolytic hyperbilirubinaemia. The addition of TB ROR can identify those infants with elimination disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14316","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T10:39:09Z","timestamp":1521110349000},"page":"1350-1356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Identification of risk for neonatal haemolysis"],"prefix":"10.1111","volume":"107","author":[{"given":"Vinod K.","family":"Bhutani","sequence":"first","affiliation":[{"name":"Department of Pediatrics Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Jeffrey","family":"Maisels","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Beaumont Children's and Oakland University William Beaumont School of Medicine Royal Oak MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Schutzman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Einstein Medical Center Philadelphia Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin E.","family":"Castillo Cuadrado","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janelle L.","family":"Aby","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra 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