{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:06:53Z","timestamp":1790719613855,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Less invasive surfactant administration (<jats:styled-content style=\"fixed-case\">LISA<\/jats:styled-content>) can avoid tracheal intubation for neonatal respiratory distress syndrome, but can be painful because it requires laryngoscopy. The aim of this study was to assess the efficacy and tolerance of intravenous atropine plus ketamine administration before <jats:styled-content style=\"fixed-case\">LISA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective observational study of all premature infants hospitalised in our French neonatal intensive care unit treated with <jats:styled-content style=\"fixed-case\">LISA<\/jats:styled-content> between March 2015 and March 2016. Ketamine was titrated by 0.5 mg\/kg increments. The technical conditions, pain scores, emergent intubations and vital signs were collected and analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Values are reported as medians (interquartile ranges). We included 29 patients with a gestational age of 29.6 (28.6\u201330.9) weeks and birth weight of 1290 (945\u20131600) grams. Technical conditions were satisfying for 24 infants (83%). The Faceless Acute Neonatal Pain Scale score was 2 (2\u20134); seven infants (24%) required tracheal intubation before <jats:styled-content style=\"fixed-case\">LISA<\/jats:styled-content> could be performed; 17 (59%) had a pulse oxymetry value under 80% that lasted more than 60 seconds. Heart rate and mean arterial blood pressure transiently increased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Atropine plus ketamine before <jats:styled-content style=\"fixed-case\">LISA<\/jats:styled-content> resulted in low pain scores and stable haemodynamic parameters, but prolonged desaturations or apnoea leading to tracheal intubation were frequently observed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14317","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T10:37:05Z","timestamp":1521110225000},"page":"1184-1190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Administering atropine and ketamine before less invasive surfactant administration resulted in low pain scores in a prospective study of premature neonates"],"prefix":"10.1111","volume":"107","author":[{"given":"L","family":"Bourgoin","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit Centre Hospitalier Intercommunal de Cr\u00e9teil Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Caeymaex","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Centre Hospitalier Intercommunal de Cr\u00e9teil Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Decobert","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Centre Hospitalier Intercommunal de Cr\u00e9teil Cr\u00e9teil France"},{"name":"Inserm U955, Team 13 Universit\u00e9 Paris Est (UPEC) Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinical Research Center Centre Hospitalier Intercommunal de Cr\u00e9teil Cr\u00e9teil 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