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Disease severity and dietary responses were also compared between coeliac children diagnosed by screening (n = 146) or because of <jats:styled-content style=\"fixed-case\">EIM<\/jats:styled-content> (n = 116) or gastrointestinal symptoms (n = 249).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Coeliac patients had more <jats:styled-content style=\"fixed-case\">EIM<\/jats:styled-content> (62%) than those with functional disorders (33%). The most common <jats:styled-content style=\"fixed-case\">EIM<\/jats:styled-content> in coeliac children were poor growth (27%) and anaemia (18%). Children with coeliac disease often showed fatigue (8%) and symptoms affecting the skin (15%), nervous system (9%) and joints (6%). Coeliac patients with <jats:styled-content style=\"fixed-case\">EIM<\/jats:styled-content> as their main clinical presentation had more severe symptoms and histological damage at diagnosis than those with gastrointestinal presentation and screen\u2010detected cases. The subgroups did not differ with regard to other clinical and laboratory parameters and dietary adherence. Concomitant <jats:styled-content style=\"fixed-case\">EIM<\/jats:styled-content> were also common in children diagnosed because of gastrointestinal presentation (60%) and by screening (37%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">EIM<\/jats:styled-content> were common in coeliac disease and associated with more severe clinical and histological presentation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14324","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T06:41:15Z","timestamp":1521787275000},"page":"681-687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Extraintestinal manifestations were common in children with coeliac disease and were more prevalent in patients with more severe clinical and histological 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