{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T16:17:29Z","timestamp":1768407449409,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Swedish Government"},{"name":"Research Foundation of the Swedish Asthma and Allergy Association"},{"name":"Gothenburg Masonic Order Orphanage Foundation"},{"name":"Health & Medical Care Committee of the Regional Executive Board"},{"name":"V\u00e4stra G\u00f6taland Region"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study explored the prevalence of atopic and nonatopic asthma in 12\u2010year\u2010old children and whether they were associated with different risk factors. In particular, we wanted to analyse whether receiving antibiotics during the first week of life was associated with asthma at that age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were obtained from a longitudinal cohort study of 5654 Swedish children born in 2003. The parents answered questionnaires from the age of six months until 12 years. The response rate at 12 years was 3637\/4777 (76%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 12 years, 6.4% reported current doctor\u2010diagnosed asthma. Treatment with antibiotics during the first week of life was associated with an increased risk of atopic asthma, with an adjusted odds ratio of 2.2 and 95% confidence interval of 1.2\u20134.2. Being born small for gestational age was associated with an increased risk of nonatopic asthma, with an adjusted odds ratio of 3.8 and 95% confidence interval of 1.1\u201313.7. Asthma that only occurred with colds was reported by 28%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antibiotic treatment during the first week of life was associated with an increased risk of atopic asthma at 12 years, suggesting an immune\u2010mediated effect. Being born small for gestational age increased the risk of nonatopic asthma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14332","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T01:22:00Z","timestamp":1522027320000},"page":"1798-1804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Antibiotics in the first week of life were associated with atopic asthma at 12 years of age"],"prefix":"10.1111","volume":"107","author":[{"given":"Frida","family":"Str\u00f6mberg Celind","sequence":"first","affiliation":[{"name":"Department of Paediatrics University of Gothenburg Queen Silvia Children's Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7010-7191","authenticated-orcid":false,"given":"G\u00f6ran","family":"Wennergren","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Gothenburg Queen Silvia Children's Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Styliana","family":"Vasileiadou","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Gothenburg Queen Silvia Children's Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3557-2995","authenticated-orcid":false,"given":"Bernt","family":"Alm","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Gothenburg Queen Silvia Children's Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9595-1877","authenticated-orcid":false,"given":"Emma","family":"Goks\u00f6r","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Gothenburg Queen Silvia Children's Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13433"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61451-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.010462"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-699X.2007.00001.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.126490"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23783"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad9378"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01685.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02379.x"},{"key":"e_1_2_11_11_1","unstructured":"Svenska Neonatalf\u00f6reningen[Swedish Neonal Society].Neonatal sepsis \u2013 ny behandlingsrekommendation[Neonatal sepsis \u2013 new treatment recommendation]. [cited 2018 Jan 30]. Available from URL:http:\/\/neo.barnlakarforeningen.se\/wp-content\/uploads\/sites\/14\/2014\/03\/infektioner_2013.pdf."},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03024.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1146"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2009.01080.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2012.10.002"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1232"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02411.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12078"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.08.050"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.03997.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12576"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu072"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02786.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13537"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030483"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.13.s.15.10.x"}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.14332","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.14332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T05:19:31Z","timestamp":1695014371000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.14332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,16]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/apa.14332"],"URL":"https:\/\/doi.org\/10.1111\/apa.14332","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"value":"0803-5253","type":"print"},{"value":"1651-2227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,16]]},"assertion":[{"value":"2017-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}