{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:03:56Z","timestamp":1772759036470,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"THL public sources"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The 10\u2010valent pneumococcal conjugate vaccine was introduced to the Finnish national vaccination programme for children born since June 2010. We evaluated the changes in the rates of clinically suspected invasive pneumococcal disease (<jats:styled-content style=\"fixed-case\">IPD<\/jats:styled-content>) in unvaccinated children to estimate the indirect herd protection impact of the programme.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The target cohort for this ecological before and after comparison were unvaccinated children born from January 2008 to May 2010 and ineligible for the vaccination programme, who were followed up from 2011 to 2014. The reference cohort was age and season\u2010matched children born in January 2003 to 2005 and followed up from 2006 to 2009. National data on hospital discharge codes compatible with <jats:styled-content style=\"fixed-case\">IPD<\/jats:styled-content> or unspecified sepsis were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We compared the follow\u2010up periods of 2007\u20132009 in the reference cohort and 2012\u20132014 in the target cohort. The incidence of non\u2010laboratory\u2010confirmed <jats:styled-content style=\"fixed-case\">IPD<\/jats:styled-content> in unvaccinated children fell by 68%, from 47 to 15\/100 000 person\u2010years. When unspecified sepsis was added, the decrease was 39%, from 171 to 104\/100 000 person\u2010years. Laboratory confirmed <jats:styled-content style=\"fixed-case\">IPD<\/jats:styled-content> fell by 44%, from 15 to 8\/100 000 person\u2010years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The pneumococcal vaccination programme provided herd protection against clinically suspected <jats:styled-content style=\"fixed-case\">IPD<\/jats:styled-content>. The absolute reduction was almost 10\u2010times higher than for just laboratory\u2010confirmed disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14335","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T01:24:51Z","timestamp":1522027491000},"page":"1610-1615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A pneumococcal conjugate vaccination programme reduced clinically suspected invasive disease in unvaccinated children"],"prefix":"10.1111","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8071-8896","authenticated-orcid":false,"given":"AA","family":"Palmu","sequence":"first","affiliation":[{"name":"Department of Public Health Solutions National Institute for Health and Welfare Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Rinta\u2010Kokko","sequence":"additional","affiliation":[{"name":"Department of Public Health Solutions National Institute for Health and Welfare Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JP","family":"Nuorti","sequence":"additional","affiliation":[{"name":"Department of Health Security National Institute for Health and Welfare Helsinki Finland"},{"name":"Department of Epidemiology, Health Sciences Faculty of Social Sciences University of Tampere Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Nohynek","sequence":"additional","affiliation":[{"name":"Department of Health Security National Institute for Health and Welfare Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Jokinen","sequence":"additional","affiliation":[{"name":"Department of Public Health Solutions National Institute for Health and Welfare Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200003000-00003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022823"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61682-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70139-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/648593"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70090-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120290"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2338"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-0458"},{"key":"e_1_2_10_11_1","unstructured":"Drug consumption at wholesale prices. 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