{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:53:24Z","timestamp":1791939204383,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T00:00:00Z","timestamp":1525651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study investigated the diagnostic usefulness of combined multichannel intraluminal impedance\u2010pH monitoring (MII\u2010pH) in children with suspected reflux\u2010related otitis media with effusion (OME) as existing data were scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective study that included children up to seven years of age who underwent MII\u2010pH due to OME lasting more than three months. The study was conducted in the Children's Hospital Zagreb, Croatia, from January 2014 to August 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study comprised 63 children (63% male) with a mean age of 4.7\u00a0years. Gastroesophageal reflux (GER) disease was detected by impedance in 22 (35%) of the children and by pH\u2010metry in nine (14%). In children with OME, MII\u2010pH found a median number of 24 proximal GER episodes, of which a median of nine was acidic and a median of 11 was weakly acidic. There was a significant positive correlation between the number of GER episodes and the presence of eosinophils in nasal swabs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both acidic and weakly acidic refluxes seemed to play a significant role in the pathogenesis of OME. Localised nasal eosinophilia may serve as a marker of extraoesophageal reflux in children with suspected reflux\u2010related OME.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14339","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T00:01:47Z","timestamp":1522454507000},"page":"1642-1647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Combined multichannel intraluminal impedance\u2010pH monitoring should be used to diagnose reflux\u2010related otitis media with effusion in children"],"prefix":"10.1111","volume":"107","author":[{"given":"Ivan","family":"Pavi\u0107","sequence":"first","affiliation":[{"name":"Department of Pulmonology, Allergology and Immunology Children's Hospital Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Babi\u0107","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department Children's Hospital Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nu\u0161a","family":"Matija\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Allergology and Immunology Children's Hospital Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"Hojsak","sequence":"additional","affiliation":[{"name":"Referral Centre for Paediatric Gastroenterology and Nutrition Children's Hospital Zagreb Zagreb Croatia"},{"name":"University of Zagreb School of Medicine Zagreb Croatia"},{"name":"University J.J. 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