{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:34:56Z","timestamp":1783571696516,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T00:00:00Z","timestamp":1526860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The traditional approach for acute paediatric osteoarticular infections (OAI) has comprised initial intravenous antibiotics followed by prompt oral antibiotics. We assessed how providing just oral antibiotics compared to the traditional two\u2010step approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective study was performed at the Hospital La Paz, Madrid, Spain, from September 2015 to September 2016. We compared 25 outpatients, with good general health and a mean age of 25 months who received just oral antibiotics, with 228 hospitalised children of a similar age who received intravenous and oral antibiotics from other hospitals in the Spanish Network of Osteoarticular Infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The groups were comparable in terms of age, sex, fever, erythrocyte sedimentation rate value, C\u2010reactive protein and diagnosis. The oral group comprised 15 with osteomyelitis, seven with septic arthritis, two with osteoarthritis and one with spondylodiscitis. This group had a lower percentage of <jats:italic>Staphylococcus aureus<\/jats:italic> (8% vs 26%, p = 0.06) and higher proportion of <jats:italic>Kingella kingae<\/jats:italic> (24% vs 9%, p = 0.017) than the intravenous group. There were complications (24%) and follow\u2010up sequelae (6%) in the intravenous group, but none in the oral group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Outpatients with OAI who were in good general health had favourable outcomes when they received oral antibiotics without intravenous antibiotics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14373","type":"journal-article","created":{"date-parts":[[2018,4,29]],"date-time":"2018-04-29T12:14:19Z","timestamp":1525004059000},"page":"1792-1797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Outpatients with acute osteoarticular infections had favourable outcomes when they received just oral antibiotics without intravenous antibiotics"],"prefix":"10.1111","volume":"107","author":[{"given":"Rosa","family":"Alcobendas","sequence":"first","affiliation":[{"name":"Pediatric Rheumatology Unit Hospital Universitario La Paz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Remesal","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit Hospital Universitario La Paz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Murias","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit Hospital Universitario La Paz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmeralda","family":"Nu\u00f1ez","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit UGC Pediatr\u00eda Hospital Materno\u2010Infantil de M\u00e1laga M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6503-3423","authenticated-orcid":false,"given":"Cristina","family":"Calvo","sequence":"additional","affiliation":[{"name":"Pediatric and Infectious Disease Department Fundaci\u00f3n IdiPaz Hospital Universitario La Paz Madrid Spain"},{"name":"Translational Research Network in Pediatric Infectious Diseases (RITIP) Madrid Spain"},{"name":"Task\u2010force in Europe for Drug Development for the Young (TEDDY) Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2012.12.006"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/597582"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piv009"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001503"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","unstructured":"McConnellJ SekkidesO.Highlights from the 27th ECCMID. 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