{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:25:13Z","timestamp":1790367913657,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T00:00:00Z","timestamp":1528416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We performed this study to examine and understand the evolving demographics and changing outcomes of intestinal failure (IF) and its implications for healthcare delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We conducted a retrospective analysis of outcome data of children on home parenteral nutrition (<jats:styled-content style=\"fixed-case\">HPN<\/jats:styled-content>), over a 15\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 31 patients received <jats:styled-content style=\"fixed-case\">HPN<\/jats:styled-content>: 15 for short bowel syndrome (<jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>), eight neuromuscular disease (<jats:styled-content style=\"fixed-case\">NMD<\/jats:styled-content>) and eight for other causes. The <jats:styled-content style=\"fixed-case\">HPN<\/jats:styled-content> prevalence increased from 1.54 per million children in 2000 to 21.5 in 2016. The outcomes over last 5 years were better than those of previous 10 years. The rate of catheter\u2010related bloodstream infection (<jats:styled-content style=\"fixed-case\">CRBSI<\/jats:styled-content>) had fallen from 4 to 1.3 and IF liver disease (<jats:styled-content style=\"fixed-case\">IFALD<\/jats:styled-content>) from 20% to 7.7%. The aetiology changed over years from <jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content> being the main cause to <jats:styled-content style=\"fixed-case\">NMD<\/jats:styled-content> contributing 43% to the total in 2016. This was especially relevant as <jats:styled-content style=\"fixed-case\">NMD<\/jats:styled-content> was associated with greater numbers of <jats:styled-content style=\"fixed-case\">IFALD<\/jats:styled-content> (38% vs 6.7%), <jats:styled-content style=\"fixed-case\">CRBSI<\/jats:styled-content> (1.51 vs 0.64\/1000 <jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content> days) and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The outcome of long\u2010term parenteral nutrition (<jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content>) has improved. The increasing number of patients with <jats:styled-content style=\"fixed-case\">NMD<\/jats:styled-content>, coupled with their higher burden of care, results in an increasing health care burden, and the planning of intestinal rehabilitation services needs to reflect this.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14401","type":"journal-article","created":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T16:04:32Z","timestamp":1526227472000},"page":"2207-2211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Intestinal failure: the evolving demographic and patient outcomes on home parenteral nutrition"],"prefix":"10.1111","volume":"107","author":[{"given":"Sarah Kate","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Paediatric Gastroenterology University Hospitals Southampton NHS Trust Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Dietetics University Hospitals Southampton NHS Trust Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enda","family":"Smyth","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology University Hospitals Southampton NHS Trust Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicky","family":"Heather","sequence":"additional","affiliation":[{"name":"Department of Dietetics University Hospitals Southampton NHS Trust Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology University Hospitals Southampton NHS Trust Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon Charles","family":"Keys","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery University Hospitals Southampton NHS Trust Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Mark","family":"Beattie","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology University Hospitals Southampton NHS Trust Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0722-4392","authenticated-orcid":false,"given":"Akshay","family":"Batra","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology University Hospitals Southampton NHS Trust Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.03.040"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2011.02.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.02.070"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31802c6971"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318268a9e3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.05.012"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2010.01.013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31817af979"},{"key":"e_1_2_10_10_1","unstructured":"Office for National Statistics.Local and health authority data on population demographics. 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