{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:30:42Z","timestamp":1771036242328,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T00:00:00Z","timestamp":1528934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Tampere Tuberculosis Foundation and the Paediatric Research Foundation of Finland"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study evaluated children hospitalised for bronchiolitis at less than six months of age to see if they had reduced lung function in early adolescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We have prospectively followed 166 children hospitalised for infant bronchiolitis in 2001\u20132004 at Tampere University Hospital, Finland. At 10\u201313\u00a0years of age, flow\u2010volume spirometry was measured in 89 cases and 108 controls without infant bronchiolitis from the local population register. Parameters of flow\u2010volume spirometry before and after bronchodilation were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forced expiratory volume in one second\/forced vital capacity (<jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">FVC<\/jats:styled-content>) after bronchodilation was lower in cases than controls. <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content>1 was pathological \u2013 under the 5th percentile of the national references \u2013 in 25% of cases and 12% of controls (p\u00a0=\u00a00.020) before bronchodilation and in 18% of cases and 5% of controls (p\u00a0=\u00a00.003) after bronchodilation. <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">FVC<\/jats:styled-content> was pathological in 25% of cases and 13% of controls (p\u00a0=\u00a00.034) before bronchodilation. Logistic regression, adjusted for current asthma and maternal smoking, showed that infant bronchiolitis was associated with pathological <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content>1 before (odds ratio 2.4) and after (odds ratio 4.4) bronchodilation. The result was similar for positive respiratory syncytial virus cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduced <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content>1 after bronchodilation was found in early adolescence after infant bronchiolitis, suggesting irreversible bronchial obstruction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14412","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T20:55:45Z","timestamp":1526936145000},"page":"124-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Prospective study confirms that bronchiolitis in early infancy increases the risk of reduced lung function at 10\u201313\u00a0years of age"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9249-1342","authenticated-orcid":false,"given":"Riikka","family":"Riikonen","sequence":"first","affiliation":[{"name":"Center for Child Health Research Tampere University and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4654-7602","authenticated-orcid":false,"given":"Eero","family":"Lauhkonen","sequence":"additional","affiliation":[{"name":"Center for Child Health Research Tampere University and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7918-3652","authenticated-orcid":false,"given":"Sari","family":"T\u00f6rm\u00e4nen","sequence":"additional","affiliation":[{"name":"Center for Child Health Research Tampere University and University Hospital Tampere 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