{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:47:47Z","timestamp":1781520467148,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002960","name":"V\u00e4sterbotten L\u00e4ns Landsting","doi-asserted-by":"publisher","award":["ALF \u2010VLL 67971"],"award-info":[{"award-number":["ALF \u2010VLL 67971"]}],"id":[{"id":"10.13039\/501100002960","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007373","name":"Stiftelsen Sven Jerrings Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>More infants born extremely preterm (EPT) are surviving, but major neonatal morbidities are consistently high. This study examined the impact of bronchopulmonary dysplasia (BPD), brain injuries and severe retinopathy of prematurity (ROP) on adolescents who were born EPT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We focused on EPT infants born at 23\u201325 weeks at the Swedish university hospitals in Uppsala and Ume\u00e5 from January 1992 to December 1998. The poor outcome data covered 140 of 142 who survived to 36 weeks, and the chronic conditions data reported by parents covered 132 of 134 still alive at 10\u201315 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 140 survivors at 36 weeks, 29 (21%) had poor outcomes: eight of 140 (6%) died, and 21 of 132 (16%) adolescent survivors had severe neurodevelopmental disabilities (NDD). BPD, severe ROP and\/or brain injuries correlated independently with poor outcome. Of those adolescents who were free from BPD, brain injury and severe ROP, 6% had a severe NDD. The corresponding rates with any one, any two or all three neonatal morbidities were 21, 33 and 67%, respectively. BPD and brain injuries were associated with high rates of chronic conditions at 10\u201315 years of age resulting in functional limitations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In adolescent EPT survivors, BPD and brain injuries were associated with high rates of chronic conditions and special healthcare needs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14445","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T06:40:52Z","timestamp":1528785652000},"page":"1893-1901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Impact of major neonatal morbidities on adolescents born at 23\u201325 weeks of gestation"],"prefix":"10.1111","volume":"107","author":[{"given":"Antti","family":"Holsti","sequence":"first","affiliation":[{"name":"Department of Pediatrics Institute of Clinical Sciences University of Ume\u00e5 Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Serenius","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Institute of Clinical Sciences University of Ume\u00e5 Ume\u00e5 Sweden"},{"name":"Department of Women's and Children's Health Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9803-6455","authenticated-orcid":false,"given":"Aijaz","family":"Farooqi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Institute of Clinical Sciences University of Ume\u00e5 Ume\u00e5 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