{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T17:12:17Z","timestamp":1747329137295,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T00:00:00Z","timestamp":1534204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We determined the safety, feasibility and sustainability of an outpatient model of care for infants exposed to intra\u2010uterine drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective chart review of 774 drug\u2010exposed infants born between 1998 and 2016 at the Royal Hospital for Women, Sydney, Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most (86%) of the mothers used multiple drugs, including opioids (58%). More than three\u2010quarters (78%) of the infants were born full term at a mean gestation of 38 weeks and hospitalised for a median of seven days. This rose to 14 days if they were medicated for neonatal abstinence syndrome (<jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>). Most of the <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content> patients (83%) were discharged on medication, namely morphine, and the median duration of <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content> treatment was 76 (interquartile range 35\u2013120). Three medication errors occurred: two extra doses of phenobarbitone and one infant weaned off morphine faster than prescribed. No infants were rehospitalised for <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>. Four died from sudden infant death syndrome at 2.2\u20135.8 months after discharge and one drowned at 15 months. None were medicated at the time of death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Outpatient care for drug\u2010exposed infants was sustainable and had low complication rates, even for those with <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>. The optimum duration of follow\u2010up and impact on hospital costs should be examined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14509","type":"journal-article","created":{"date-parts":[[2018,7,21]],"date-time":"2018-07-21T14:48:06Z","timestamp":1532184486000},"page":"654-661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Retrospective study found that outpatient care for infants exposed to drugs during pregnancy was sustainable and safe"],"prefix":"10.1111","volume":"108","author":[{"given":"R","family":"Rasul","sequence":"first","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Kensington NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Ward","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Kensington NSW Australia"},{"name":"The Royal Hospital for Women Randwick NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Clews","sequence":"additional","affiliation":[{"name":"The Langton Centre Surry Hills NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Falconer","sequence":"additional","affiliation":[{"name":"The Langton Centre Surry Hills NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Feller","sequence":"additional","affiliation":[{"name":"Sydney Children's Hospital Randwick NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Lui","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Kensington NSW Australia"},{"name":"The Royal Hospital for Women Randwick NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7799-3771","authenticated-orcid":false,"given":"J","family":"Oei","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Kensington NSW Australia"},{"name":"The Royal Hospital for Women Randwick NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13842"},{"key":"e_1_2_11_3_1","first-page":"141","article-title":"Neonatal abstinence syndrome: assessment and management","volume":"2","author":"Finnegan LP","year":"1975","journal-title":"Addict Dis"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.114"},{"key":"e_1_2_11_5_1","first-page":"255","article-title":"Congenital morphinism: report of a case","volume":"70","author":"Perlstein MA","year":"1945","journal-title":"Am J Dis Child"},{"key":"e_1_2_11_6_1","first-page":"7","article-title":"Methadone disposition during the perinatal period in humans","volume":"11","author":"Kreek MJ","year":"1979","journal-title":"Pharmacol Biochem Behav"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2012.02471.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2001.00657.x"},{"key":"e_1_2_11_9_1","unstructured":"NSW Department of Health Mental Health and Drug and Alcohol Office Neonatal Abstinence Syndrome Guidelines.2013. 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