{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:42:04Z","timestamp":1761986524970,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study assessed the prevalence, clinical presentation and outcome of lymphocytic colitis (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>) and eosinophilic gastrointestinal disease (<jats:styled-content style=\"fixed-case\">EGID<\/jats:styled-content>) in children with severe, recurrent abdominal pain (<jats:styled-content style=\"fixed-case\">RAP<\/jats:styled-content>), by describing the predominant symptoms, diagnostic approaches and treatment options.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective follow\u2010up study at a Danish regional hospital by reviewing the histology reports of the children who had undergone gastrointestinal endoscopy for <jats:styled-content style=\"fixed-case\">RAP<\/jats:styled-content>. Data were retrieved from the medical records of those who met the diagnostic criteria for <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> and, or, <jats:styled-content style=\"fixed-case\">EGID<\/jats:styled-content> from 2011 to 2016. The study population comprised 381 patients who underwent a diagnostic process to clarify <jats:styled-content style=\"fixed-case\">RAP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 74 patients (39 females) aged 2\u201317 years, with severe <jats:styled-content style=\"fixed-case\">RAP<\/jats:styled-content> as the most predominant symptom underwent gastrointestinal endoscopy. This identified 16\/74 (21.6%) with <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> (n = 6) and, or, <jats:styled-content style=\"fixed-case\">EGID<\/jats:styled-content> (n = 11), which equated to 4.2% with <jats:styled-content style=\"fixed-case\">RAP<\/jats:styled-content>. No biochemical patterns of abnormalities were found. Medical treatment and, or, diet generally induced and maintained clinical remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found 16 children with <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> and, or, <jats:styled-content style=\"fixed-case\">EGID<\/jats:styled-content>. The predominant symptom was severe <jats:styled-content style=\"fixed-case\">RAP<\/jats:styled-content>. All patients had a macroscopically normal mucosa at endoscopy, a specific histopathological feature and no characteristic biochemical findings. Endoscopy should be considered in these cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14520","type":"journal-article","created":{"date-parts":[[2018,7,28]],"date-time":"2018-07-28T06:34:16Z","timestamp":1532759656000},"page":"154-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Retrospective study recommends endoscopy when diagnosing lymphocytic colitis or eosinophilic gastrointestinal disorder in children with abdominal pain"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5343-1128","authenticated-orcid":false,"given":"Jens","family":"Tilma","sequence":"first","affiliation":[{"name":"Sygehus Lilleb\u00e6lt Vejle Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen","family":"Tilma","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Tilma","sequence":"additional","affiliation":[{"name":"Boernelaegeklinikken\/v Karen Tilma Broenderslev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.07.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2015038"},{"key":"e_1_2_11_4_1","first-page":"193","article-title":"The pediatric Rome IV criteria: what's new?","volume":"11","author":"Koppen IJ","year":"2017","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.06.001"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04865.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181eb5a9f"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0964-4"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182a1df59"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2014.11.009"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2014.11.009"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.06.004"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.5223\/pghn.2015.18.4.253"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-015-0558-5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-015-8489-4"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12948-016-0055-y"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1549365"},{"key":"e_1_2_11_18_1","first-page":"35","article-title":"Zur Kenntnis der allergischen affektionen des verdauungskanals vom standpunkt des chirurgen aus","volume":"188","author":"Kaijser R","year":"1936","journal-title":"Archiv f\u00fcr Klinische Chirurgie"},{"key":"e_1_2_11_19_1","unstructured":"JungeO FallingborgJ Tage\u2010JensenU HansenJ LarsenL. [website]Stool disorders 2016. Available at:https:\/\/www.sundhed.dk\/sundhedsfaglig\/information-til-praksis\/nordjylland\/patientforloeb\/forloebsbeskrivelser\/d-fordoejelsesorganer\/afforingsforstyrrelser\/(accessed on October 27 2016)."},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2014.3994"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12197"},{"key":"e_1_2_11_22_1","first-page":"98","article-title":"Advances in knowledge on microscopic colitis: from bench to bedside","volume":"107","author":"Guagnozzi D","year":"2015","journal-title":"Rev Esp Enferm Dig"},{"key":"e_1_2_11_23_1","first-page":"273","article-title":"Diagnosis and management of microscopic colitis: current perspectives","volume":"7","author":"Bohr J","year":"2014","journal-title":"Clin Exp Gastroenterol"},{"key":"e_1_2_11_24_1","unstructured":"Sundhedsstyrelsen (The National Board of Health) [Report]. The Danish Healthcare System.2005."}],"container-title":["Acta Paediatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapa.14520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.14520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apa.14520","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apa.14520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:04:33Z","timestamp":1694754273000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apa.14520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,22]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/apa.14520"],"URL":"https:\/\/doi.org\/10.1111\/apa.14520","archive":["Portico"],"relation":{},"ISSN":["0803-5253","1651-2227"],"issn-type":[{"type":"print","value":"0803-5253"},{"type":"electronic","value":"1651-2227"}],"subject":[],"published":{"date-parts":[[2018,8,22]]},"assertion":[{"value":"2018-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}