{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:45:12Z","timestamp":1789076712955,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We assessed the risk factors for transient acute kidney injury in very low birth weight (<jats:styled-content style=\"fixed-case\">VLBW<\/jats:styled-content>) infants treated for patent ductus arteriosus (<jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>) using the serum creatinine\u2010based criteria in Kidney Disease: Improving Global Outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This retrospective study of infants requiring ibuprofen and, or, surgery for haemodynamic relevant <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>s was performed at the University Children's Hospital of Saarland, Homburg, Germany, from January 2009 to December 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We studied 422 infants with a mean birth weight of 1059 \u00b1 308.2 g. Acute kidney injuries developed in 150\/295 infants (50.9%) with spontaneous <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> closure, in 46\/82 (56.1%) who received intravenous ibuprofen treatment, in 18\/24 (75.0%) who had surgery and in 15\/21 infants (71.4%) who received both medical and surgical treatment. Acute kidney injuries were associated with birth weight and gestational age, Apgar scores at 10 minutes, the <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> size corrected for birth weight, a <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> with three affected circulatory territories, <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> surgery and gentamicin. Multiple logistic regression analysis showed particular associations between acute kidney injury and birth weight (p = 0.001), the 10\u2010minute Apgar score (p = 0.02) and gentamicin (p = 0.043).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Birth weight, the 10\u2010minute Apgar score and gentamicin were particularly associated with acute kidney injuries in our cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.14563","type":"journal-article","created":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T06:37:51Z","timestamp":1536043071000},"page":"645-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Birth weight, Apgar scores and gentamicin were associated with acute kidney injuries in <scp>VLBW<\/scp> neonates requiring treatment for patent ductus 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